 Home > Encyclopedia > Garenoxacin

Garenoxacin

Garenoxacin structure

CAS No:
194804-75-6
Formula:
C23H20F2N2O4
Chemical Name:
Garenoxacin
Synonyms:
3-Quinolinecarboxylic acid,1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-;3-Quinolinecarboxylic acid,1-cyclopropyl-8-(difluoromethoxy)-7-(2,3-dihydro-1-methyl-1H-isoindol-5-yl)-1,4-dihydro-4-oxo-,(+)-;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;Garenoxacin;T 3811;Ganefloxacin;Garenfloxacin;(R)-1-Cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;345632-74-8
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by a cyclopropyl group at position 1, an oxo group at position 4, a (1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl group at po ition 7, and a difluoromethoxy group at position 8.Garenoxacin is a new quinolone antimicrobial agent that exhibits a broad spectrum of activity against both Gram-negative and Gram-positive organisms, including the important community-acquired respiratory pathogens S

Garenoxacin is a quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by a cyclopropyl group at position 1, an oxo group at position 4, a (1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl group at position 7, and a difluoromethoxy group at position 8. It has a role as an antibacterial drug and a non-steroidal anti-inflammatory drug. It is a quinolone antibiotic, a quinolinemonocarboxylic acid, an organofluorine compound, a member of cyclopropanes, an aromatic ether and a member of isoindoles.|Garenoxacin, a quinolone antibiotic, is being investigated for the treatment of gram-positive and gram-negative bacterial infections.

Garenoxacin Basic Attributes

Molecular Weight：

426.41

Exact Mass：

426.41

UNII：

V72H9867WB

DSSTox ID：

DTXSID30173135

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

78.9

XLogP3：

2.28

Density：

1.421±0.06 g/cm3(Predicted)

Melting Point：

226-227°; mp 234-235°

Boiling Point：

581.5±50.0 °C(Predicted)

Flash Point：

305.5±30.1 °C

Refractive Index：

1.631

Specific rotation：

D27 -9.0° (c = 0.10 in N,N-dimethylformamide)

Drug Information

Drug Indication：

Investigated for use/treatment in bacterial infection.

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

MeSH Entry Terms：

BMS 284756

Garenoxacin Use and Manufacturing

Des-F(6)-quinolone antibacterial; topoisomerase II inhibitor. Antibacterial.

Computed Properties

Molecular Weight:426.4
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:426.13911345
Monoisotopic Mass:426.13911345
Topological Polar Surface Area:78.9
Heavy Atom Count:31
Complexity:771
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Garenoxacin

JHECHEM CO LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of BBiochemicals,Peptides,Silicones,Pharmaceuticals,Building blocks,Intermediates

Garenoxacin

CAS No.: 194804-75-6

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Garenoxacin

CAS No.: 194804-75-6

Content: 99.00%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

Garenoxacin cas 194804-75-6

Unit Price: $50 /MT EXW

CAS No.: 194804-75-6

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Chongqing Chemdad Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Amino acid,intermediates

Garenoxacin

CAS No.: 194804-75-6

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

High purity Garenoxacin 99% high quality see COA KANBEI

CAS No.: 194804-75-6

Grade: Industrial Grade

Content: 99%

Inquiry