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Ritodrine hydrochloride

Ritodrine hydrochloride structure

CAS No:
23239-51-2
Formula:
C17H21NO3.ClH
Chemical Name:
Ritodrine hydrochloride
Synonyms:
Benzenemethanol,4-hydroxy-α-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-,hydrochloride (1:1),(αS)-rel-;Benzyl alcohol,p-hydroxy-α-[1-[(p-hydroxyphenethyl)amino]ethyl]-,hydrochloride,erythro-;Benzenemethanol,4-hydroxy-α-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-,hydrochloride,(R*,S*)-;Benzenemethanol,4-hydroxy-α-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-,hydrochloride,(αS)-rel-;Ritodrine hydrochloride;DU 21220;Yutopar;Pre-Par;(±)-Ritodrine hydrochloride;Miolene;Prempar;Utemerin;Utopar;NSC 291565;52447-11-7
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.Target: β-2 Adrenergic ReceptorRitodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCTs for different gestational ages and different labour stages should be designed for further study [1]. Ritodrine is a beta-2 adrenergic receptor agonist - a class of medica

Ritodrine hydrochloride is a primary amine.|An adrenergic beta-2 agonist used to control PREMATURE LABOR.

Ritodrine hydrochloride Basic Attributes

Molecular Weight：

323.81

Exact Mass：

323.128815

EC Number：

245-514-8

DSSTox ID：

DTXSID8045438

ATC Code：

G - Genito urinary system and sex hormones

HScode：

2922504500

Characteristics

PSA：

72.72000

XLogP3：

3.54490

Density：

1.213 g/cm3

Melting Point：

193-195 °C (decomp)

Boiling Point：

512.3ºC at 760 mmHg

Flash Point：

175.6ºC

Storage Conditions：

-20°C Freezer

Collision Cross Section：

166.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

DO6524000

Marks：

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)|Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

MeSH Entry Terms：

DU 21220

Ritodrine hydrochloride Use and Manufacturing

Uses

Tocolytic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:323.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:323.1288213
Monoisotopic Mass:323.1288213
Topological Polar Surface Area:72.7
Heavy Atom Count:22
Complexity:284
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It acts on the β2 receptors of uterine smooth muscle, thereby inhibiting the contraction frequency and intensity of uterine smooth muscle. It is a drug that can be taken orally, intramuscularly, or intravenously to effectively prolong pregnancy and prevent premature birth.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ritodrine Hydrochloride Tablets
Ingredients	Ritodrine hydrochloride.
Indication	1. Avoid using it with beta-receptor agonists and inhibitors. 2. Using corticosteroids at the same time may cause pulmonary edema. 3. It may cause hypertension in the presence of parasympathetic blockers such as atropine. 4. When used with other parasympathetic amines, the cardiovascular effects are enhanced. However, this can be avoided as long as there is enough time interval. Because 90% of ritodrine is excreted from the body within 24 hours of administration. 5. Anesthetics used in surgery should consider that the effects on hypotensive patients may be enhanced.
Specifications	10mg

Ritodrine Hydrochloride Tablets
Ingredients	Ritodrine hydrochloride.
Indication	1. Avoid using it with beta-receptor agonists and inhibitors. 2. Using corticosteroids at the same time may cause pulmonary edema. 3. It may cause hypertension in the presence of parasympathetic blockers such as atropine. 4. When used with other parasympathetic amines, the cardiovascular effects are enhanced. However, this can be avoided as long as there is enough time interval. Because 90% of ritodrine is excreted from the body within 24 hours of administration. 5. Anesthetics used in surgery should consider that the effects on patients with hypotension may be enhanced.
Specifications	10mg
Manufacturer	Hainan Zhuotai Pharmaceutical Co., Ltd.

Ritodrine Hydrochloride for Injection
Specifications	50mg

See More Related Drugs

Registered Holders

Hainan Wuren Pharmaceutical Co., Ltd.

China
Active
Suzhou Lixin Pharmaceutical Co., Ltd.

China
Active
Jumpcan Pharmaceutical Group Co., Ltd.

China
Active

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4-hydroxy-a-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-

CAS No.: 23239-51-2

Grade: Industrial Grade

Content: 99.5%

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Ritodrine Hcl CAS 23239-51-2

CAS No.: 23239-51-2

Grade: Pharmaceutical Grade

Content: 99%

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