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Verapamil hydrochloride

Verapamil hydrochloride structure

CAS No:
23313-68-0
Formula:
C27H39ClN2O4
Chemical Name:
Verapamil hydrochloride
Synonyms:
CALAN;IPROVERATRIL;(+/-)-5-[N-(3,4-DIMETHOXYPHENYLETHYL)-METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE;5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE;alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride;ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE;5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE;(+/-)-VERAPAMIL HYDROCHLORIDE
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

White Powder

Verapamil hydrochloride (VRP) is a phenylalkylamine calcium ion influx inhibitor (calcium antagonist). Verapamil hydrochloride exerts its pharmacologic effects by modulating the influx of ionic through the slow channels of vascular smooth muscle and cardiac cell membranes. It is widely used for the treatment of hypertension, angina pectoris, supraventricular tachycardia, myocardial infraction, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines The plasma half-life of verapamil hydrochloride is 2–7 hours, which necessitates multiple dosing. After oral administration of VRP to humans, the drug is rapidly absorbed and widely distributed. It is approximately 90% absorbed from the gastrointestinal tract but is subject to considerable first pass metabolism and its bioavailability is around 20–30%. The low bioavailability is owing to the rapid biotransformation in the liver with a biological half-life of 4.0±1.5 hours.

The salt is purified by dissolving it in EtOH, filtering (if insoluble particles are present) and adding Et2O, filtering the salt, washing it with Et2O and drying it in vacuo. It has the following solubilities: hexane (0.001%), CH2Cl2 (~10%), MeOH (~10%), EtOH (20%) and H2O (8.3%). It has UV max at 232 and 278nm. The free base is a viscous yellow oil b 243-246o/0.01mm (n 25D 1.5448) and is almost insoluble in H2O but soluble in organic solvents. It is a Ca channel antagonist and is a coronary vasodilator. [Ramuz Helv Chim Acta 58 2050 1975, Harvey et al. Biochem J 257 95 1989.]

Verapamil hydrochloride Basic Attributes

Molecular Weight：

491.06

Exact Mass：

490.259827

EC Number：

245-579-2

Color/Form：

white

HScode：

2926909090

Characteristics

PSA：

XLogP3：

5.89508

Appearance：

white powder

Melting Point：

142 °C (dec.)(lit.)

Boiling Point：

586.1ºC at 760 mmHg

Flash Point：

308.3ºC

Water Solubility：

methanol: 50 mg/mL, clear, colorless

Storage Conditions：

0-6°C

Critical Temperature & Pressure：

0-6°C

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

T,Xi

safety instructions：

36/37-45-37/39-26

RTECS Number：

YV8320000

Marks：

T,Xi

Precautionary statement(s)：

P260, P261, P264, P270, P271, P273, P280, P284, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P311, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501

Hazard Statements：

23/24/25-36/37/38

RIDADR：

UN 2811 6.1/PG 3

Verapamil hydrochloride Use and Manufacturing

Calcium antagonists

A calcium channel blocker. Antihypertensive; antianginal; antiarrhythmic (class IV)

Recommended Suppliers of Verapamil hydrochloride

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CN
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Verapamil hydrochloride1kg

CAS No.: 23313-68-0

Grade: Pharmaceutical Grade

Content: 99%

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Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

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Verapamil hydrochloride 23313-68-0

CAS No.: 23313-68-0

Grade: Pharmaceutical Grade

Content: 99%

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