L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3)
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L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3)
structure -
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CAS No:
41372-08-1
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Formula:
C10H13NO4.3/2H2O
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Chemical Name:
L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3)
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Synonyms:
L-Tyrosine,3-hydroxy-α-methyl-,hydrate (2:3);(-)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
L-(-)-α-Methyldopa hydrate is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.Target: alpha-adrenergic agonistMethyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise diffi
Methyldopa is a phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.|An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3) Basic Attributes
229.23
476.20061
209-089-2
56LH93261Y
DTXSID5020863
C47616
2922504500
Characteristics
113.01000
0.13
White Solid
1.4±0.1 g/cm3
>300 °C(lit.)
441.6±45.0 °C at 760 mmHg
220.9±28.7 °C
1.635
0.1-1 g/100 mL at 23 ºC
Refrigerator
Safety Information
NONH for all modes of transport
3
20/21-36/37/38-42/43-65
24/25
YP2860000
Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.
|Danger|H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)
Aldomet
L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3) Use and Manufacturing
Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.?
Computed Properties
Molecular Weight:476.5
Hydrogen Bond Donor Count:11
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:6
Exact Mass:476.20060984
Monoisotopic Mass:476.20060984
Topological Polar Surface Area:211
Heavy Atom Count:33
Complexity:246
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
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L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3)
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