 Home > Encyclopedia > cefsulodin sodium salt

cefsulodin sodium salt

cefsulodin sodium salt structure

CAS No:
52152-93-9
Formula:
C22H20N4O8S2.Na
Chemical Name:
cefsulodin sodium salt
Synonyms:
pseudocef;pseudomonil;pyocefal;pyridinium,4-(aminocarbonyl)-1-[[(6r,7r)-2-carboxy-8-oxo-7-[[(2r)-phenylsulfoa;sce129;sulcephalosporin;takesulin;Sodium (6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[[(2R)-2-phenyl-2-sulfonatoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Cefsulodin sodium salt hydrate is a third generation β lactam antibiotic and member of the cephems subgroub of antibiotics. Target: AntibacterialThe compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-

Cefsulodin was synthesized by Takeda Chemicals Industries in 1974 by introducing the sulfobenzyl group, the same moiety as in sulbenicillin, at the 7 position of the cephem nucleus. Its side chain at the 3 position is similar to that of cephaloridine except for the carbamoyl group. The introduction of these hydrophilic groups increases the activity against Pseudomonas aeruginosa, but it markedly decreases it against gram-positive and other gramnegative bacteria. Therefore cefsulodin is used as a specific antibiotic against infections caused by the opportunistic pathogen P. aeruginosa.

ChEBI: Cefsulodin sodium is an organic molecular entity.

cefsulodin sodium salt Basic Attributes

Molecular Weight：

555.54

Exact Mass：

554.054199

EC Number：

257-692-4

TSCA：

TSCA listed

DSSTox ID：

DTXSID6045585

Color/Form：

Off-White to Pale Yellow

HScode：

29419059

Characteristics

PSA：

227.39000

XLogP3：

-0.12670

Appearance：

White to pale yellow crystalline powder

Melting Point：

175 C

Water Solubility：

Soluble in water.

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice (mg/kg): >4000 i.p.; >15000 orally (Bryskier)

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, sodium oxide fumes

Critical Temperature & Pressure：

Inert atmosphere,Store in freezer, under -20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Xi,Xn

safety instructions：

22-26-36/37-45-36

RTECS Number：

UU1785000

Marks：

Xi,Xn

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

36/37/38-42/43-20/21/22

GHS Classification：

|Danger|H315 (96.08%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 51 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

practically nontoxic

cefsulodin sodium salt Use and Manufacturing

Uses

A β lactam antibiotic.

Cefsulodin is most commonly used in CIN agar to select for Yersinia microorganisms. The compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-resistant mutants of Pseudomonas aeruginosa PAO4089 growth displayed that Cefsulodin sodium salt hydrate may compete with PBP3 in addition to PBP1A and PBP1B.

betaadrenergic blocker

Cefsulodin is a third generation cephalosporin (C258750) antibiotic designed specifically for Pseudomonas Aeruginosa.

Manufacturing Info：

Pyridinium, 4-(aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, sodium salt (1:1): ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:572.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:572.06476489
Monoisotopic Mass:572.06476489
Topological Polar Surface Area:228
Heavy Atom Count:38
Complexity:1040
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Recommended Suppliers of cefsulodin sodium salt

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Cefsulodine sodium antibiocs pharmaceutical supplier Diminish inflammation

CAS No.: 52152-93-9

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

cefsulodin sodium salt1KG

Unit Price: $10000 /Unit EXW

CAS No.: 52152-93-9

Grade: Industrial Grade

Inquiry