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Eperisone hydrochloride

Eperisone hydrochloride structure

CAS No:
56839-43-1
Formula:
C17H25NO.ClH
Chemical Name:
Eperisone hydrochloride
Synonyms:
1-Propanone,1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-,hydrochloride (1:1);1-Propanone,1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-,hydrochloride;Myonal;E 0646;4′-Ethyl-2-methyl-3-piperidinopropiophenone hydrochloride;Eperisone hydrochloride;EMPP;Mional;(±)-Eperisone hydrochloride;Skelact;Rapisone;Myosone plus
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a

Eperisone hydrochloride is an aromatic ketone.

Eperisone hydrochloride Basic Attributes

Molecular Weight：

295.85

Exact Mass：

295.17000

EC Number：

1308068-626-2

DSSTox ID：

DTXSID8047844

Characteristics

PSA：

20.3

XLogP3：

4.29360

Appearance：

white or similar to white crystalline powder with peculiar smell and bitter taste

Density：

0.994g/cm3

Melting Point：

170-172 °C

Boiling Point：

386.8°C at 760 mmHg

Flash Point：

137.4ºC

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 in male S.D. rats, Wistar rats, mice (mg/kg): 1300, 1850, 1024 orally (Miyagawa)

Drug Information

MeSH：

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)|A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

(4'-ethyl-2-methyl-3-piperidino)propiophenone

Eperisone hydrochloride Use and Manufacturing

A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).

Computed Properties

Molecular Weight:295.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:295.1702921
Monoisotopic Mass:295.1702921
Topological Polar Surface Area:20.3
Heavy Atom Count:20
Complexity:275
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Central skeletal muscle relaxants can inhibit decerebrate tonicity and reflex potentials and reduce the sensitivity of muscle spindles; they have the effects of calcium antagonists and block muscle sympathetic nerves, dilate blood vessels and increase blood flow; they also have analgesic effects at the spinal cord level.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Eperisone Hydrochloride
Manufacturer	Hunan Yada Pharmaceutical Co., Ltd.

Eperisone Hydrochloride Tablets
Ingredients	EperisoneHCl, 4-ethyl-2-methyl-3-piperidinylpropiophenone hydrochloride, has a molecular formula of C17H25NO·HCl and a molecular weight of 295.85.
Indication	There have been reports of ocular accommodation disorders when a similar drug, tolperisone hydrochloride, is used in combination with methoxycarbamol.
Specifications	50mg

Eperisone Hydrochloride Tablets
Ingredients	EperisoneHCl, 4-ethyl-2-methyl-3-piperidinylpropiophenone hydrochloride, has a molecular formula of C17H25NO·HCl and a molecular weight of 295.85.
Indication	There have been reports of ocular accommodation disorders when a similar drug, tolperisone hydrochloride, is used in combination with methoxycarbamol.
Specifications	50mg
Manufacturer	Qingdao Guohai Biopharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

株式会社パーマケム・アジア

Japan
Active
Anhui Tingworld Pharmaceutical Co., Ltd.

China
Active
Hunan Yada Pharmaceutical Co., Ltd.

China
Active

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CAS No.: 56839-43-1

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Eperisone Hydrochloride 56839-43-1

CAS No.: 56839-43-1

Grade: Pharmaceutical Grade

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