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Celiprolol hydrochloride

Celiprolol hydrochloride structure

CAS No:
57470-78-7
Formula:
C20H33N3O4.ClH
Chemical Name:
Celiprolol hydrochloride
Synonyms:
Urea,N′-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-,hydrochloride (1:1);Urea,N′-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-,monohydrochloride;ST 1396;Celiprolol hydrochloride;REV 5320A;Celectol;Selecor;Corliprol;NSC 324509;Tenoloc
Categories:
Organic Chemistry > Amides

Description

White Crystalline Solid

Celiprolol hydrochloride is an aromatic ketone.|A cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.

Celiprolol hydrochloride Basic Attributes

Molecular Weight：

415.95

Exact Mass：

415.223785

EC Number：

260-752-2

NSC Number：

324509

DSSTox ID：

DTXSID0046850

Characteristics

PSA：

90.9

XLogP3：

4.09720

Density：

1.114g/cm3

Melting Point：

197-200 °C (decomp)

Boiling Point：

586.5ºC at 760 mmHg

Flash Point：

308.5ºC

Water Solubility：

Soluble in ethanol, methanol and water

Storage Conditions：

Refrigerator

Toxicity：

LD50 in male mice, rats (mg/kg): 56.2, 68.3 i.v.; 1834, 3826 orally (Wendtlandt, Pittner)

Safety Information

RTECS Number：

YR6560000

Precautionary statement(s)：

P273, P501

Hazard Statements：

H412

GHS Classification：

H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|Aggregated GHS information provided by 54 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Celiprolol

Celiprolol hydrochloride Use and Manufacturing

antihypertensive antianginal;beta blocker

Computed Properties

Molecular Weight:416.0
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:415.2237843
Monoisotopic Mass:415.2237843
Topological Polar Surface Area:90.9
Heavy Atom Count:28
Complexity:474
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Celiprolol Hydrochloride
Manufacturer	Zhejiang Hisun Pharmaceutical Co., Ltd.

Celiprolol Hydrochloride Capsules
Ingredients	The main component of this product is celiprolol hydrochloride, the chemical name is 3-[3-acetyl-4-(3-tert-butylamino-2-hydroxy-propoxy)-phenyl]-1,1-diethylurea hydrochloride, the chemical structure is as follows: Molecular formula: C20H33N3O4·HCl Molecular weight: 415.96
Indication	When used in combination with adrenergic neuron blocking drugs such as reserpine, their effects are additive, and sometimes postural hypotension and bradycardia, even dizziness and syncope, may occur. Both verapamil and beta-blockers can slow down A-V conduction and inhibit myocardial contractility, but their mechanisms of action are different. When switching from verapamil to this product or from this product to verapamil, a drug withdrawal period is recommended. If continuous administration is required, ECG monitoring should be used at the beginning. Patients with existing conduction abnormalities should not use the two drugs together. Be careful when using it in combination with Class I antiarrhythmic drugs such as proglumide. Food can reduce the bioavailability of this product, and it may also reduce the bioavailability of this product when used in combination with chlorthalidone and hydrochlorothiazide.
Specifications	0.1g
Manufacturer	FuJian Pacific Pharmaceutical Co., Ltd.

Celiprolol Hydrochloride
Manufacturer	Southwest Synthetic Pharmaceutical Corp.,ltd.

Registered Holders

MOEHS IBERICA SL

Spain
Active
Zhejiang Hisun Pharmaceutical Co., Ltd.

China
Active
Southwest Synthetic Pharmaceutical Corp.,ltd.

China
Active

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