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Bevantolol

Bevantolol structure

CAS No:
59170-23-9
Formula:
C20H27NO4
Chemical Name:
Bevantolol
Synonyms:
2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-;1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol;Bevantolol;DL-Bevantolol;(±)-Bevantolol;NSC 132348;1-((3,4-Dimethoxyphenethyl)amino)-3-(m-tolyloxy)propan-2-ol;91476-05-0
Categories:
Organic Chemistry > Amides

Description

Solid

Bevantolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension. It has a role as a beta-adrenergic antagonist, a calcium channel blocker, an antihypertensive agent and an anti-arrhythmia drug.|Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.

Bevantolol Basic Attributes

Molecular Weight：

345.436

Exact Mass：

345.43

NSC Number：

132348

ATC Code：

C - Cardiovascular system

HScode：

2922299090

Characteristics

PSA：

XLogP3：

3.00

Appearance：

Solid

Density：

1.1±0.1 g/cm3

Melting Point：

137-138 °C

Boiling Point：

518.3±50.0 °C at 760 mmHg

Flash Point：

267.3±30.1 °C

Refractive Index：

1.551

Water Solubility：

1.37e-02 g/L

Drug Information

Drug Indication：

For the treatment of angina pectoris and hypertension.

Pharmacology：

Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.

MeSH：

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

Mechanism of Action：

Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. By binding and antagonizing beta-1 receptors Bevantolol inhibits the normal normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure.

MeSH Entry Terms：

bevantolol

Computed Properties

Molecular Weight:345.4
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:345.19400834
Monoisotopic Mass:345.19400834
Topological Polar Surface Area:60
Heavy Atom Count:25
Complexity:355
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes