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Betaxolol hydrochloride

Betaxolol hydrochloride structure

CAS No:
63659-19-8
Formula:
C18H29NO3.ClH
Chemical Name:
Betaxolol hydrochloride
Synonyms:
2-Propanol,1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-,hydrochloride (1:1);2-Propanol,1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-,hydrochloride;Betaxolol hydrochloride;Betoptic;SL 75212;Kerlone;SLD 212;Betoptima;Betapress;Optipress;Lusopress;72424-72-7
Categories:
Organic Chemistry > Amides

Description

Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.Target: Beta1 Adrenergic ReceptorBetaxolol is a cardioselective beta-adrenergic receptor blocking agent. Betaxolol (5 mg/kg via i.p. injection) was administered at 24 and then 44 h following the final chronic cocaine administration. Animals treated with betaxolol during cocaine withdrawal exhibited a significant attenuation of anxiety-like behavior characterized by

A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.

Betaxolol hydrochloride Basic Attributes

Molecular Weight：

343.89

Exact Mass：

343.191437

EC Number：

264-384-3

NSC Number：

760048

HScode：

2922199090

Characteristics

PSA：

50.7

XLogP3：

3.58630

Appearance：

white solid

Melting Point：

116 °C

Boiling Point：

448ºC at 760 mmHg

Flash Point：

224.7ºC

Water Solubility：

H2O: 36 mg/mL, soluble

Storage Conditions：

Store at RT

Toxicity：

LD50 in mice (mg/kg): 944 orally; 37 i.v. (Manoury)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

UA9823000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 49 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)|Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

MeSH Entry Terms：

Alcon, Betaxolol

Betaxolol hydrochloride Use and Manufacturing

Uses

antifungal

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:343.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:11
Exact Mass:343.1914215
Monoisotopic Mass:343.1914215
Topological Polar Surface Area:50.7
Heavy Atom Count:23
Complexity:286
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

1. Betaxolol hydrochloride is a cardioselective β1-adrenergic receptor blocker; 2. It does not have a cell membrane stabilizing effect, so it does not affect the sensitivity of the cornea; 3. It does not have endogenous sympathomimetic activity; 4. It can reduce the intraocular pressure of patients with high intraocular pressure or glaucoma; 5. It exerts an intraocular pressure-lowering effect by reducing the production of aqueous humor; 6. It has minimal adverse reactions to the heart and lungs; 7. It does not inhibit the effect of isoproterenol; 8. It has little effect on blood pressure and heart rate; 9. It has no carcinogenic, mutagenic or teratogenic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Betaxolol hydrochloride eye drops
Ingredients	Betaxolol hydrochloride.
Indication	1. If other adrenergic receptor blockers are taken orally at the same time, drug additive reactions may occur; 2. If you are taking drugs that promote catecholamine metabolism (such as reserpine), adrenergic receptor blockers may cause additive reactions, resulting in hypotension or bradycardia; 3. If adrenergic receptor blockers with psychotropic effects are used, their adverse reactions should be noted; 4. Because betaxolol does not have a miotic effect, miotic agents must be used at the same time to control high intraocular pressure caused by angle-closure glaucoma.
Specifications	5ml:12.5mg (in terms of betaxolol)

Betaxolol Hydrochloride Tablets
Specifications	20 mg

Betaxolol Hydrochloride
Manufacturer	Shan DONG Seamountain Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

INDOCO REMEDIES LTD

United States
Active
FINORGA S.A.S.

Japan
Active
LUSOCHIMICA SPA

Brazil
Active

See More Registered Holders

Recommended Suppliers of Betaxolol hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Betaxolol hydrochloride

CAS No.: 63659-19-8

Content: 99.00%

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