 Home > Encyclopedia > Naftifine

Naftifine

Naftifine structure

CAS No:
65472-88-0
Formula:
C21H21N
Chemical Name:
Naftifine
Synonyms:
1-Naphthalenemethanamine,N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-;1-Naphthalenemethanamine,N-methyl-N-(3-phenyl-2-propenyl)-,(E)-;1-Naphthalenemethanamine,N-methyl-N-[(2E)-3-phenyl-2-propenyl]-;N-Methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine;Naftifine;Naftifungin;Nafetifine
Categories:
Organic Chemistry > Amides

Description

ChEBI: A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.

Naftifine is a tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor and a sterol biosynthesis inhibitor. It is a member of naphthalenes, a tertiary amine and an allylamine antifungal drug.|Naftifine is an Allylamine Antifungal.|Naftifine is a topical, synthetic allylamine derivate similar to terbinafine with broad-spectrum antifungal activity. Naftifine can be fungicidal or fungistatic depending on the concentration and the organisms involved.

Naftifine Basic Attributes

Molecular Weight：

323.87

Exact Mass：

287.40

UNII：

4FB1TON47A

DSSTox ID：

DTXSID6048545

NCI Thesaurus Code：

C66217

ATC Code：

D - Dermatologicals

HScode：

2921499090

Characteristics

PSA：

3.2

XLogP3：

5.4

Density：

1.082 g/cm3

Melting Point：

177 °C

Boiling Point：

162-167 °C @ Press: 0.015 Torr

Flash Point：

194.4ºC

Safety Information

wgk germany：

hazard class code：

R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

S26

RTECS Number：

DB7350000

Marks：

Xn,Xi

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

N-cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride

Naftifine Use and Manufacturing

Broad-spectrum topical antifungal drugs. Mainly used for anti-skin fungi, its efficacy is better than drugs such as hair ringworm, clotrimazole, meconazole and econazole, with low toxicity.

Computed Properties

Molecular Weight:287.4
XLogP3:5.1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:287.167399674
Monoisotopic Mass:287.167399674
Topological Polar Surface Area:3.2
Heavy Atom Count:22
Complexity:342
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Paraformaldehyde

Formaldehyde

Recommended Suppliers of Naftifine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

High Quality Naftifine 99% liquid 65472-88-0 Shaanxi Dideu Medichem Co.Ltd

Unit Price: $1 /G FOB

CAS No.: 65472-88-0

Grade: Chemical Grade

Content: 99%

Inquiry
SHANDONG LOOK CHEMICAL CO.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate,Pigment & Dyestuff,Polymer,Flavour & Fragrance,Basic Organic Chemicals,Pharmaceutical

Naftifine65472-88-0

Unit Price: $1-1.1 /KG FOB

CAS No.: 65472-88-0

Inquiry