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Amorolfine

Amorolfine structure

CAS No:
67467-83-8
Formula:
C21H35NO
Chemical Name:
Amorolfine
Synonyms:
AMOROLFINE;cis-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine;(2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;(2R,6S)-4-[3-(4-tert-amylphenyl)-2-methyl-propyl]-2,6-dimethyl-morpholine;Amorolfine/4-[3-[4-(11-Dimethylpropyl)phenyl]-2-methylpropyl]-26-dimethylmorpholine;Amorolfine Impurity 22;Voriconazole Impurity 97;Amorofen
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

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Amorolfine Basic Attributes

Molecular Weight：

317.51

Exact Mass：

317.271851

EC Number：

1312995-182-4

Color/Form：

Colourless

Characteristics

PSA：

12.47000

XLogP3：

5.73

Appearance：

white crystalline powder

Density：

0.924±0.06 g/cm3(Predicted)

Boiling Point：

407.1±33.0 °C(Predicted)

Flash Point：

119.6±27.7 °C

Refractive Index：

1.489

PKA：

7.33±0.10(Predicted)

Critical Temperature & Pressure：

Refrigerator, under inert atmosphere

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

amorolfin hydrochloride

Amorolfine Use and Manufacturing

Broad-spectrum and highly effective antifungal drugs

Amorolfine is available for topical use in 0.25% cream and 5% nail lacquer formulation for the treatment of onychomycosis in European countries and Japan. However, amorolfine is not approved in the USA for such indications. The major advantage of this new antimycotic drug presumably lies in its potential for use as 5% nail lacquer in the treatment of onychomycosis caused by dermatophytes and Candida spp.

Antimycotic.

Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease.

Computed Properties

Molecular Weight:317.5
XLogP3:5.7
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:317.271864740
Monoisotopic Mass:317.271864740
Topological Polar Surface Area:12.5
Heavy Atom Count:23
Complexity:336
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has a killing effect on various fungi that can cause nail infections

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Amorolfine hydrochloride liniment
Ingredients	This ointment contains 50mg/ml (5%) of the active ingredient amorolfine and its excipients: methacrylic acid polymer 150000, triacetin, butyl acetate, ethyl acetate, ethanol. Each package contains a 2.5ml bottle of ointment and a cleaning swab, nail spatula and nail file.
Specifications	5%

Amorolfine hydrochloride liniment
Ingredients	This product contains 55.74 mg of the main ingredient, amorolfine hydrochloride, per milliliter (equivalent to 50 mg of amorolfine).
Indication	If used on the treated nails or toenails at the same time as other drugs, drug interactions may occur. Please consult your physician or pharmacist for details.
Specifications	5％2.5ml1bottle