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Amorolfine hydrochloride

Amorolfine hydrochloride structure

CAS No:
78613-38-4
Formula:
C21H35NO.ClH
Chemical Name:
Amorolfine hydrochloride
Synonyms:
Morpholine,4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-,hydrochloride (1:1),(2R,6S)-rel-;Morpholine,4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-,hydrochloride,cis-;Morpholine,4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-,hydrochloride,(2R,6S)-rel-;Ro 14-4767/002;Amorolfine hydrochloride;83094-51-3
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Amorolfine hydrochloride is a antifungal reagent.Target: AntifungalAmorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species [1]. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneou

Amorolfine hydrochloride is a hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used for the topical treatment of fungal nail and skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor, an EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor and an EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor. It is a hydrochloride and a morpholine antifungal drug. It contains an amorolfine(1+).|Amorolfine Hydrochloride is the hyrochloride salt form of amorolfine, a morpholine antifungal agent. Amorolfine inhibits delta-14-reductase and delta-7,8-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membrane.

Amorolfine hydrochloride Basic Attributes

Molecular Weight：

353.97

Exact Mass：

353.248535

EC Number：

276-715-9

UNII：

741YH7379H

DSSTox ID：

DTXSID80229217

NCI Thesaurus Code：

C81507

HScode：

29411010

Characteristics

PSA：

12.5

XLogP3：

5.40190

Appearance：

white to beige

Density：

1.234

Boiling Point：

120 C

Water Solubility：

DMSO: ≥5mg/mL (warmed)

Storage Conditions：

room temp

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

20/21/22-36/37/38-50/53-38-22

safety instructions：

26-36-61

Marks：

Xn,N

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302-H315-H411

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

amorolfin hydrochloride

Amorolfine hydrochloride Use and Manufacturing

antihypertensive

Computed Properties

Molecular Weight:354.0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:353.2485425
Monoisotopic Mass:353.2485425
Topological Polar Surface Area:12.5
Heavy Atom Count:24
Complexity:336
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

By changing the biosynthesis of lipids that constitute the fungal cell membrane, the ergosterol content is reduced, and the accumulation of atypical lipids leads to changes in the morphology of the fungal cell membrane and organelles, thereby achieving an antibacterial effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Amorolfine hydrochloride liniment
Ingredients	Amorolfine hydrochloride, its chemical name is: rac-cis-4[3-[4-(1,1-dimethyl-propyl)phenyl]-2-methylpropane]-2,6-dimethyl-morpholine hydrochloride.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	5% (calculated as amorolfine)
Manufacturer	Jiangsu Fubang Pharmaceutical Co., Ltd.

Amorolfine hydrochloride cream
Ingredients	The main ingredients of this product are: Amorolfine hydrochloride. The structural formula of rac-cis-4[3-[4-(1,1-dimethyl-propyl)phenyl]-2-methylpropane]-2,6-dimethyl-morpholine hydrochloride is: The pictures related to this topic are as follows: Molecular formula: C21H35NO, HCL Molecular weight: 353.98
Indication	It is not clear yet.
Specifications	0.25%
Manufacturer	Jiangsu Fubang Pharmaceutical Co., Ltd.

Amorolfine hydrochloride liniment
Ingredients	Amorolfine hydrochloride, its chemical name is: rac-cis-4[3-[4-(1,1-dimethyl-propyl)phenyl]-2-methylpropane]-2,6-dimethyl-morpholine hydrochloride.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	2.5ml:0.125g (in terms of amorolfine)
Manufacturer	Zhejiang Deyer Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Yichang Nuoan Pharmaceutical Co., Ltd.

China
Active
Guangzhou Greensyn Pharma Co., Ltd.

China
Active
Anhui Yongshengtang Pharmaceutical Limited Liability Company

China
Active

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