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Fenticonazole nitrate

Fenticonazole nitrate structure

CAS No:
73151-29-8
Formula:
C24H20Cl2N2OS.HNO3
Chemical Name:
Fenticonazole nitrate
Synonyms:
1H-Imidazole,1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-,nitrate (1:1);1H-Imidazole,1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-,mononitrate;Feniconazole nitrate;REC 15-1476;Fentiderm;Fenticonazole nitrate;Falvin
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Fenticonazole Nitrate is an azole antifungal agent.Target: AntifungalFenticonazole is an azole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Application of fenticonazole nitrate 1 g intravaginal ovules on 2 alternate days is a suitable first-line treatment of vulvovaginitis with acceptable broad-spectrum efficacy against the mos

Fenticonazole nitrate is a racemate comprising equimolar amounts of (R)- and (S)-fenticonazole nitrate. Used for the treatment of vaginal candidiasis. It has a role as an antibacterial drug. It is a racemate, an imidazole antifungal drug and a conazole antifungal drug. It contains a (S)-fenticonazole nitrate and a (R)-fenticonazole nitrate.

Fenticonazole nitrate Basic Attributes

Molecular Weight：

518.41

Exact Mass：

517.062988

EC Number：

277-302-6

HScode：

2942000000

Characteristics

PSA：

118

XLogP3：

7.47470

Density：

1.26g/cm3

Melting Point：

136 °C

Boiling Point：

637.2ºC at 760 mmHg

Flash Point：

339.2ºC

Refractive Index：

1.632

Storage Conditions：

Refrigerator

Toxicity：

LD50 in mice, male rats, female rats (mg/kg): 1191, 440, 309 i.p.; all >3000 orally (Graziani)

Safety Information

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

safety instructions：

S26

RTECS Number：

NI4780000

Marks：

Xi,Xn

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

1-(2,4-dichloro-beta-((p-(phenylthio)benzyl)oxy)phenethyl)imidazole

Fenticonazole nitrate Use and Manufacturing

Broad spectrum antimycotic; also active as antibacterial. Antifungal (topical).

Computed Properties

Molecular Weight:518.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:517.0629827
Monoisotopic Mass:517.0629827
Topological Polar Surface Area:118
Heavy Atom Count:34
Complexity:524
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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