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Metoprolol succinate

Metoprolol succinate structure

CAS No:
98418-47-4
Formula:
C15H25NO3.¹/2C4H6O4
Chemical Name:
Metoprolol succinate
Synonyms:
Butanedioic acid,compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2);Butanedioic acid,compd. with (±)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2);2-Propanol,1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-,(±)-,butanedioate (2:1) (salt);2-Propanol,1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-,butanedioate (2:1) (salt);Metoprolol succinate;Toprol XL;Seloken-Zok;Betaloc Zok;Betaloc CR;Beloc-Zok;Selozok;Betazok;H 93/26 succinate;122404-82-4;1149342-75-5
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Metoprolol Succinate (Toprol XL) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.IC50 value:Target: β1 receptor

Metoprolol succinate is an alcohol and a member of phenols.|A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.

Metoprolol succinate Basic Attributes

Molecular Weight：

652.82

Exact Mass：

652.393494

EC Number：

1312995-182-4

DSSTox ID：

DTXSID9048726

HScode：

2922509090

Characteristics

PSA：

176

XLogP3：

3.94400

Boiling Point：

398.6ºC at 760 mmHg

Flash Point：

194.9ºC

Water Solubility：

Freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent), very slightly soluble in ethyl acetate.

Safety Information

Precautionary statement(s)：

P260

Hazard Statements：

H370

GHS Classification：

|Danger|H302 (11.76%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P302+P352, P307+P311, P321, P330, P332+P313, P362, P405, and P501|Aggregated GHS information provided by 51 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Beloc Duriles

Metoprolol succinate Use and Manufacturing

Uses

Anti - hypertensives

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:652.8
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:21
Exact Mass:652.39349599
Monoisotopic Mass:652.39349599
Topological Polar Surface Area:176
Heavy Atom Count:46
Complexity:308
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Metoprolol succinate extended-release tablets
Specifications	95mg

Metoprolol succinate extended-release tablets
Ingredients	Metoprolol succinate.
Indication	Divide into 2, N
Specifications	95 mg

Metoprolol succinate extended-release tablets
Ingredients	Metoprolol succinate.
Indication	Divide into 2, N
Specifications	47.5 mg

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Registered Holders

KOPRAN RESEARCH LABORATORIES LTD

United States
Active
MSN LIFE SCIENCES PRIVATE LTD

United States
Active
INDOCO REMEDIES LTD

United States
Active

See More Registered Holders

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