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Cefotetan disodium

Cefotetan disodium structure

CAS No:
74356-00-6
Formula:
C17H17N7O8S4.2Na
Chemical Name:
Cefotetan disodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:2),(6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,disodium salt,[6R-(6α,7α)]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,disodium salt,(6R,7S)-;1,3-Dithietane,5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid deriv.;YM 09330;Yamatetan;Cefotetan sodium;Cefotetan disodium;Cepan Darvilen;Ceftenon;Apatef;Cefotan;82189-60-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefotetan disodium is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis[1].

Cefotetan disodium is the disodium salt of cefotetan. It has a role as an antibacterial drug. It contains a cefotetan(2-).|Cefotetan Disodium is the disodium salt form of cefotetan and a semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic with bactericidal activity. Cefotetan disodium causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. This results in a reduction of cell wall stability and causes cell lysis.|A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.

Cefotetan disodium Basic Attributes

Molecular Weight：

619.58264

Exact Mass：

618.96600

EC Number：

277-834-9

NCI Thesaurus Code：

C47437

Characteristics

PSA：

327

XLogP3：

0.27540

Boiling Point：

798℃

Water Solubility：

Freely soluble in aqueous solution

Storage Conditions：

2-8°C

Toxicity：

Intravenous-rat LD50: 6700 mg/kg; Intravenous-mouse LD50: 4990 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, sodium oxide fumes

Safety Information

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36

RTECS Number：

XI0330600

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Danger|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P272, P280, P285, P302+P352, P304+P341, P305+P351+P338, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

practically nontoxic

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Apacef

Cefotetan disodium Use and Manufacturing

Uses

Antibacterial.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:619.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:7
Exact Mass:618.96603372
Monoisotopic Mass:618.96603372
Topological Polar Surface Area:327
Heavy Atom Count:38
Complexity:1080
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Cefotetan disodium

CAS No.: 74356-00-6

Content: 99.00%

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