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Sodium nigericin

Sodium nigericin structure

CAS No:
28643-80-3
Formula:
C40H68O11.Na
Chemical Name:
Sodium nigericin
Synonyms:
Nigericin,sodium salt (1:1);Nigericin,monosodium salt;1,6-Dioxaspiro[4.5]decane,nigericin deriv.;Nigericin sodium salt;Sodium nigericin;NSC 292567
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.

Sodium nigericin Basic Attributes

Molecular Weight：

746.94

Exact Mass：

746.458130

HScode：

29419090

Characteristics

PSA：

145.20000

XLogP3：

4.37090

Density：

1.19g/cm3

Melting Point：

approximate 255℃

Boiling Point：

779.9ºC at 760mmHg

Flash Point：

226.9ºC

Water Solubility：

Soluble in chloroform, methanol or ethanol

Storage Conditions：

2-8°C

Vapor Pressure：

4.26E-28mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1

Transport codes：

UN34626.1/PG3

wgk germany：

hazard class code：

25-36/37/38

safety instructions：

26-36/37/39-45

RTECS Number：

QT6840000

Marks：

Precautionary statement(s)：

P261-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H315-H319-H335

Sodium nigericin Use and Manufacturing

Nigericin sodium is a salt of the atypical polyether antibiotic, nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.