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Concanavalin A

Concanavalin A structure

CAS No:
11028-71-0
Chemical Name:
Concanavalin A
Synonyms:
Concanavalin A;Concanavaline A;Con A;Lectins,concanavalins A;Concanavalins A;12612-33-8
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.

Concanavalin A Basic Attributes

Molecular Weight：

552.6

Exact Mass：

552.20023317

EC Number：

291-083-4

DSSTox ID：

DTXSID3037202

HScode：

35040090

Characteristics

Appearance：

powder

Flash Point：

39 °C

Water Solubility：

Slightly soluble in water and phosfate buffered saline.PBS: 5 mg/mL, slightly hazy

Storage Conditions：

2-8°C

Toxicity：

Intravenous-mouse LD50: 50 mg/kg; peritoneal-mouse LD50: 41.5 mg/kg

Flammability characteristics：

Flammable, spicy and irritating smoke emitted from the fire

Safety Information

Transport codes：

UN 1170 3/PG 3

wgk germany：

hazard class code：

10-42/43-63-40-20/21/22

safety instructions：

36-24/25-45-36/37-23-22

RTECS Number：

GK6890000

Marks：

Storage features：

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P342 + P311

Hazard Statements：

H317-H334-H361

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P261, P272, P280, P281, P285, P302+P352, P304+P341, P308+P313, P321, P333+P313, P342+P311, P363, P405, and P501|Aggregated GHS information provided by 6 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed) (See all compounds classified as Mitogens.)

MeSH Entry Terms：

Concanavalin A

Concanavalin A Use and Manufacturing

Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.

Computed Properties

Molecular Weight:552.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:10
Exact Mass:552.20023317
Monoisotopic Mass:552.20023317
Topological Polar Surface Area:176
Heavy Atom Count:38
Complexity:858
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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