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Cefoselis sulfate

Cefoselis sulfate structure

CAS No:
122841-12-7
Formula:
C19H22N8O6S2.H2O4S
Chemical Name:
Cefoselis sulfate
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-,(6R,7R)-,sulfate (1:1);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-,[6R-[6α,7β(Z)]]-,sulfate (1:1) (salt);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-,(6R,7R)-,sulfate (1:1) (salt);FK 037;Cefoselis sulfate;Winsef;144739-70-8;147025-56-7
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefoselis is a new fourth-generation cephalosporin and was launched in Japan as a parenteral antibiotic for a variety of infections including Staphylococcus aureus (particularly the methicillin-resistant MRSA) and Pseudornonas aeruginosa. It can be prepared in 3 related ways, all using 2- pyrazolomethyl-3-cephem-4-carboxylic as the key intermediate. In preclinical studies, Cefolesis had better MIC50s than Ceftazidime against Streptococcus pneurnoniae or Staphflococcus aureus (methicillin-

Cefoselis sulfate Basic Attributes

Molecular Weight：

620.64

Exact Mass：

620.077759

EC Number：

1533716-785-6

DSSTox ID：

DTXSID8046795

Characteristics

PSA：

337.67000

XLogP3：

0.02710

Cefoselis sulfate Use and Manufacturing

antibiotic

Computed Properties

Molecular Weight:620.6
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:9
Exact Mass:620.07775251
Monoisotopic Mass:620.07775251
Topological Polar Surface Area:334
Heavy Atom Count:40
Complexity:1100
Defined Atom Stereocenter Count:1
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It inhibits the synthesis of bacterial cell walls, has high affinity for S. aureus and PBP1, 2 and 3, and has affinity for E. coli in the order of PBP3, 1b, 1a, 4. It has a broad antibacterial spectrum, including Gram-positive bacteria (such as Staphylococcus, Pneumococcus, Streptococcus) and Gram-negative bacteria (such as Pseudomonas, Escherichia coli, Klebsiella, Enterobacter, Serratia, Proteus, Morganella, Providencia). It is stable and has low affinity for β-lactamase produced by various bacteria, and has antibacterial activity against β-lactamase-producing bacteria.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ceftriaxone Sulfate for Injection
Ingredients	The main ingredient of this product is ceftriaxone sulfate. Chemical name: (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetylamino]-3-[5-amino-1-(2-hydroxyethyl)-1-pyrazolium]methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxy monosulfate.
Indication	Note for combined use: Warfarin: It has an enhancing effect on warfarin, but no adverse reports have been found for this preparation. This preparation has an inhibitory effect on intestinal bacteria, which may inhibit the synthesis of vitamin K. Diuretics (furosemide, etc.): May aggravate renal dysfunction. The mechanism is unclear, but other cephalosporin antibiotics have been reported to aggravate renal dysfunction. Contraindications: This preparation is prone to reduced potency or precipitation when used in combination with the following drugs, so please do not use it in combination. 1) Aminophylline preparations can lead to reduced potency. 2) This product can form precipitation when used in combination with potassium canrenoate preparations, gabexate mesylate preparations, hydroxycortisone succinate preparations, and acyclovir preparations.
Specifications	0.5g (calculated as ceftriaxone)
Manufacturer	Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Ceftriaxone sulfate
Manufacturer	Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

Registered Holders

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

China
Active

Recommended Suppliers of Cefoselis sulfate

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

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Cefoselis sulfate JP15 Pharmaceutical Antibiotics made in china

CAS No.: 122841-12-7

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