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Dalbavancin

Dalbavancin structure

CAS No:
171500-79-1
Formula:
C88H100Cl2N10O28
Chemical Name:
Dalbavancin
Synonyms:
Ristomycin A aglycone,5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-O-α-D-mannopyranosyl-N15-methyl-;5,31-Dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-O-α-D-mannopyranosyl-N15-methylristomycin A aglycone;Dalbavancin;Dalbavancin B0;BI 397;VER 001;MDL 63397;A-A 1;Dalvance;B 7011;247175-55-9
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

ChEBI: A semisynthetic glycopeptide used for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-positive microorganisms including MRSA.Dalbavancin is a second generation, semi-synthetic lipoglycopeptide antibiotic that is active against gram-positive pathogens with a MIC90for Staphylococcus aureus of 0.06 μg/mL. Dalbavancin possesses more potent in vitro bactericidal activity than vancomycin or teicopla

Dalbavancin Basic Attributes

Molecular Weight：

1816.71

Exact Mass：

1816.69

Characteristics

PSA：

572.51000

XLogP3：

2.94

Density：

1.59

Refractive Index：

1.729

Dalbavancin Use and Manufacturing

Dalbavancin is a semi-synthetic glycopeptide prepared from A40926 by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vivo half life, and improved in vitro activity against a variety of Gram positive and multi-drug resistant isolates such as MRSA and MRSE.

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CAS No.: 171500-79-1

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Guide of Dalbavancin

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Basic Attributes
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