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Idoxifene

Idoxifene structure

CAS No:
116057-75-1
Formula:
C28H30INO
Chemical Name:
Idoxifene
Synonyms:
Pyrrolidine,1-[2-[4-[(1E)-1-(4-iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]-;Pyrrolidine,1-[2-[4-[1-(4-iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]-,(E)-;Pyrrolidine,1-[2-[4-[(1E)-1-(4-iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]-;1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]pyrrolidine;CB 7432;Idoxifene;SB 223030;531553-45-4
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

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Description

CB7432 is a novel tissue-specific selective estrogen receptor modulator (SERM).

Idoxifene Basic Attributes

Molecular Weight：

523.45

Exact Mass：

523.45

UNII：

456UXE9867

DSSTox ID：

DTXSID5043926

HScode：

2933990090

Characteristics

PSA：

12.5

XLogP3：

9.50

Density：

1.329

Melting Point：

108-109° (McCague et al.)

Boiling Point：

573.4±50.0 °C(Predicted)

Flash Point：

300.6±30.1 °C

Refractive Index：

1.623

Vapor Pressure：

3.72E-13mmHg at 25°C

Drug Information

MeSH：

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)

MeSH Entry Terms：

1-(4-iodophenyl)-1-(4-(2-pyrrolidinoethoxy)phenyl)-2-phenyl-1-butene

Idoxifene Use and Manufacturing

SERM for treatment of urogenital atrophy weak estrogen and antiestrogen in uterus

Computed Properties

Molecular Weight:523.4
XLogP3:8.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:523.13721
Monoisotopic Mass:523.13721
Topological Polar Surface Area:12.5
Heavy Atom Count:31
Complexity:547
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes