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Peplomycin

Peplomycin structure

CAS No:
68247-85-8
Formula:
C61H88N18O21S2
Chemical Name:
Peplomycin
Synonyms:
Bleomycinamide,N1-[3-[[(1S)-1-phenylethyl]amino]propyl]-;N1-[3-[[(1S)-1-Phenylethyl]amino]propyl]bleomycinamide;Pepleomycin;Bleomycin PEP;Peplomycin;69308-18-5;70223-25-5;71247-73-9
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

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Peplomycin Basic Attributes

Molecular Weight：

1473.59

Exact Mass：

1473.59

EC Number：

269-484-0

Characteristics

PSA：

696

XLogP3：

0.00

Density：

1.6±0.1 g/cm3

Refractive Index：

1.689

Storage Conditions：

-20°C

Toxicity：

Intravenous-rat LD50: 215 mg/kg; Intravenous-mouse LD50: 45 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxide and sulfur oxide gas

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

highly toxic

Peplomycin Use and Manufacturing

Methods of Manufacturing

Method 1: Synthesis method. The following free acid copper salts of bleomycin and N-(1-phenylethyl)propanediamine are reacted in dimethylformamide in the presence of cyclohexylcarbodiimide to obtain pelomycin . Method 2: Fermentation method. To the fermentation broth of Streptomyces verticillus ATCCl5003 strain, N-(1-phenylethyl)propylenediamine was added for fermentation culture. The filtrate of the culture broth is further purified with Amberlite IRC-50 (H+ type) ion exchange resin to obtain pelomycin.

Uses

Antitumor antibiotics. It is clinically used for the treatment of squamous cell carcinoma, such as head squamous cell carcinoma, tongue cancer, mouth floor cancer, buccal mucosa cancer, skin squamous cell carcinoma, and malignant lymphoma. It also has a certain effect on lung cancer, prostate cancer, and malignant melanoma.

Computed Properties

Molecular Weight:1473.6
XLogP3:-6.7
Hydrogen Bond Donor Count:21
Hydrogen Bond Acceptor Count:32
Rotatable Bond Count:38
Exact Mass:1472.58128424
Monoisotopic Mass:1472.58128424
Topological Polar Surface Area:696
Heavy Atom Count:102
Complexity:2740
Undefined Atom Stereocenter Count:20
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes