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Clorsulon

Clorsulon structure

CAS No:
60200-06-8
Formula:
C8H8Cl3N3O4S2
Chemical Name:
Clorsulon
Synonyms:
1,3-Benzenedisulfonamide,4-amino-6-(1,2,2-trichloroethenyl)-;1,3-Benzenedisulfonamide,4-amino-6-(trichloroethenyl)-;4-Amino-6-(1,2,2-trichloroethenyl)-1,3-benzenedisulfonamide;4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide;L 631529;MK 401;Clorsulon;Curatrem
Categories:
Analytical Chemistry > Standard

Description

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A

4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a sulfonamide and a member of benzenes.

Clorsulon Basic Attributes

Molecular Weight：

380.66

Exact Mass：

380.66

EC Number：

262-100-2

UNII：

EG1ZDO6LRD

NSC Number：

758901

DSSTox ID：

DTXSID8045488

HScode：

2935009090

Characteristics

PSA：

163

XLogP3：

1.2

Density：

1.8±0.1 g/cm3

Melting Point：

203 °C

Boiling Point：

651.7°C at 760 mmHg

Flash Point：

348.0±34.3 °C

Refractive Index：

1.665

Storage Conditions：

0-6°C

Toxicity：

LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

CZ9090000

Precautionary statement(s)：

P264, P280, P305+P351+P338, P33, P313

Hazard Statements：

H319

GHS Classification：

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)|Agents used to treat cestode, trematode, or other flatworm infestations in man or animals. (See all compounds classified as Antiplatyhelmintic Agents.)

MeSH Entry Terms：

4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide

Clorsulon Use and Manufacturing

Methods of Manufacturing

substance ethanol 100ml, Water 350ml, Stirring, Ammonia was added20 g, Activated carbon 2g, Heated to reflux for 1 hour, Hot filtration, Using 50 ml of ethanol and100kg water washed carbon residue, The filtrate was slowly cooled to 10 ° C, Filtration, dry, The chlorine Shulong finished 16. 5g, The yield was 82.5percent.

Uses

A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes)

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals

Computed Properties

Molecular Weight:380.7
XLogP3:1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:378.902181
Monoisotopic Mass:378.902181
Topological Polar Surface Area:163
Heavy Atom Count:20
Complexity:604
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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