Flutrimazole
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Flutrimazole
structure -
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CAS No:
119006-77-8
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Formula:
C22H16F2N2
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Chemical Name:
Flutrimazole
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Synonyms:
1H-Imidazole,1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-;1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole;Flutrimazole;UR 4056;1-[(2-Fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
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CAS No:
Description
Flutrimazole is an imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is a member of imidazoles, a member of monofluorobenzenes and an imidazole antifungal drug.
Flutrimazole Basic Attributes
346.37
346.37
D - Dermatologicals|G - Genito urinary system and sex hormones
Characteristics
17.8
4.95
1.2±0.1 g/cm3
164-167 °C
457.1±40.0 °C at 760 mmHg
230.3±27.3 °C
1.590
4.16E-08mmHg at 25°C
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)
1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole
Computed Properties
Molecular Weight:346.4
XLogP3:4.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:346.12815484
Monoisotopic Mass:346.12815484
Topological Polar Surface Area:17.8
Heavy Atom Count:26
Complexity:445
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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