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Flutrimazole

Flutrimazole structure

CAS No:
119006-77-8
Formula:
C22H16F2N2
Chemical Name:
Flutrimazole
Synonyms:
1H-Imidazole,1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-;1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole;Flutrimazole;UR 4056;1-[(2-Fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
Categories:
Analytical Chemistry > Standard

Description

Flutrimazole is an imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is a member of imidazoles, a member of monofluorobenzenes and an imidazole antifungal drug.

Flutrimazole Basic Attributes

Molecular Weight：

346.37

Exact Mass：

346.37

ATC Code：

D - Dermatologicals|G - Genito urinary system and sex hormones

Characteristics

PSA：

17.8

XLogP3：

4.95

Density：

1.2±0.1 g/cm3

Melting Point：

164-167 °C

Boiling Point：

457.1±40.0 °C at 760 mmHg

Flash Point：

230.3±27.3 °C

Refractive Index：

1.590

Vapor Pressure：

4.16E-08mmHg at 25°C

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

MeSH Entry Terms：

1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole

Computed Properties

Molecular Weight:346.4
XLogP3:4.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:346.12815484
Monoisotopic Mass:346.12815484
Topological Polar Surface Area:17.8
Heavy Atom Count:26
Complexity:445
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes