4,5-Dichloro-2-fluorobenzoic acid

To a stirred solution of (Int-IG) (26 mg, 0.12 mmol, 1 equiv) in dry DMF (2 mL) was added EDCI (35 mg, 0.18 mmol, 1.5 equiv), HOBt (24 mg, 0.18 mmol, 1.5 equiv), To To a solution of 4, 5-dichloro-2-fluoro-benzoic acid (5.0 g, 24 mmol) in tetrahydrofuran (50 mL) at 0 C was added borane -tetrahydrofuran complex (1 M, 60 mL, 60 mmol) dropwise over 30 minutes. The resulting solution was stirred at 30 C for 14 hours until TLC analysis showed the reaction was complete. The reaction was quenched carefully with methanol (10 mL) and then concentrated in vacuo to give compound A-21 (4.50 g, 85% yield) as a yellow oil, which was used in the next step without further purification. LCMS (DD): (ES+) m/z (M+H)+ = 176.9, tR=0.859 min.

Molecular Weight:209.00
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:207.9494129
Monoisotopic Mass:207.9494129
Topological Polar Surface Area:37.3
Heavy Atom Count:12
Complexity:188
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes