2,3,4-Trifluorobenzaldehyde
-
2,3,4-Trifluorobenzaldehyde
structure -
-
CAS No:
161793-17-5
-
Formula:
C7H3F3O
-
Chemical Name:
2,3,4-Trifluorobenzaldehyde
-
Synonyms:
Benzaldehyde,2,3,4-trifluoro-;2,3,4-Trifluorobenzaldehyde;887586-11-0
- Categories:
-
CAS No:
Characteristics
17.1
1.7
Clear colorless Liquid
1.404 g/mL at 25 °C(lit.)
77-79 °C20 mm Hg(lit.)
133 °F
n 20/D 1.482(lit.)
0.039mmHg at 25°C
Safety Information
Ⅲ
IRRITANT
UN 1989 3/PG 3
3
36/37/38-22
26-36/37/39-37/39
Xi,Xn
Irritant
P261-P305 + P351 + P338
H226-H315-H319-H335
|Warning|H226 (89.36%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 47 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2,3,4-Trifluorobenzaldehyde Use and Manufacturing
Compound 4 (1140 g, 3 mol) and anhydrous THF (7.5 L) were added to a 30 L reaction flask and stirred. Compound 5 (566 g, 3.45 mol), compound 6 (502 g, 1.1 mol) and N-methylmorpholine (760 g, 7.5 mol) were added. The reaction solution was refluxed (60 C.) for 20 hours, cooled to 5 C. to 10 C., added with isobutyl chloroformate (492 g, 3.6 mol, dissolved in 500 mL THF) dropwise, and reacted at 5 C. to 10 C. for 1 hour. After the intermediate carboxylic acid was completely reacted, the reaction was quenched by the addition of water (3 L). Ethyl acetate (9 L) was added for extraction and the organic phase was washed with water (3 L) once, concentrated to give a mother liquor of 2.2 kg. The mother liquid was dissolved in ethyl acetate (3 L), added with tetrahydrofuran (500 mL), slowly added dropwise within-heptane (about 9 L), and stirred at 15 C. overnight to precipitate a solid. The solid was recrystallized from tetrahydrofuran/ethyl acetate/n-heptane solvent system (5 mL/5 mL/10 mL/g) to obtain 500 g compound 8A, of which the purity reached 96%, ee value>96% and yield was 27.1%.
Computed Properties
Molecular Weight:160.09
XLogP3:1.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:160.01359920
Monoisotopic Mass:160.01359920
Topological Polar Surface Area:17.1
Heavy Atom Count:11
Complexity:151
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2,3,4-Trifluorobenzaldehyde
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine
Learn More Other Chemicals
-
4-(Trifluoromethyl)benzeneacetic acid
32857-62-8
-
3-BROMO-2-FLUORO-6-PICOLINE
375368-78-8
-
2,4-Diisopropylphenol
2934-05-6
-
1,2-Diiodotetrafluoroethane Formula
354-65-4
-
6-METHYL-2-PIPERIDINECARBOXYLICACID Formula
99571-58-1
-
2,4-Dichloro-6-picoline Formula
42779-56-6
-
1-BROMO-1H,1H,2H,2H-PERFLUORODECANE Structure
21652-57-3
-
Perfluorohexanoic acid Structure
307-24-4
-
What is 6-chloro-2-naphthalenethiol
392330-26-6
-
What is 2,3-Dichloro-5-nitropyridine
22353-40-8