2-ETHYLBENZALDEHYDE

2-ethylbromobenzene (6g, 32.4mmol) was dissolved in dry 100 ml of dichloromethane, then cooled to -75 C, and t-butyl lithium cyclohexane solution was added dropwise.2.5mol/L (18ml), the dropping time is 0.5 hours, The control temperature does not exceed -65 C during the dropwise addition, and after the addition is completed, the reaction is carried out at -75 C for 1 hour.Then, 3.7 ml of DMF solution was added to keep the reaction for 1 hour, and the plate was tested, and the saturated ammonium chloride solution was quenched, washed with water, dried, and concentrated under reduced pressure to obtain a colorless solution (4.27 g, yield 99%).EXAMPLE 127 [0720] Preparation of (2S)-(-)-3-[(2R, 4R)-4-(4-Ethylbenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl]-1-(1H-2-methylindol-4-yl)oxy-2-propanol. [CHEMMOL-00214] [0721] Preparation of ( )-N, N-Dimethyl-2-(2-ethylphenyl)-2-hydroxythioacetamide. [0722] A solution of 30.11 g of 1-bromo-2-ethylbenzene in ca. 500 mL of freshly distilled THF was treated with 112 mL of 1.6 M n-BuLi in hexanes at -78 C. over a period of ca. 3 h. To this was added 15 mL of anhydrous DMF, and the mixture was stirred at -78 C. for 30 min. The cold bath was removed, and the reaction was quenched with ca. 300 mL of saturated aqueous NH4Cl. The layers were separated, and the organic layer was washed with ca. 300 mL of brine. The aqueous layers were back extracted with 2×500 mL of EtOAc. Combined organic layers were dried over MgSO4, concentrated, and dried under house vacuum to yield 20.89 g (96%) of fairly clean crude Synthesis of 1-(4-ethyl-indan-1-yl)-3-(2-fluoro-ethyl)-urea The title compound was generated from commercially available 1-bromo2-ethylbenzene according to the scheme above.

A volatile derivative of benzaldehyde present in animal-derived food products.

Molecular Weight:134.17
XLogP3:2.5
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:134.073164938
Monoisotopic Mass:134.073164938
Topological Polar Surface Area:17.1
Heavy Atom Count:10
Complexity:109
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes