Trisodium phosphonoformate hexahydrate
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Trisodium phosphonoformate hexahydrate
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CAS No:
34156-56-4
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Formula:
CH3O5P.6H2O.3Na
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Chemical Name:
Trisodium phosphonoformate hexahydrate
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Synonyms:
Phosphinecarboxylic acid,1,1-dihydroxy-,1-oxide,sodium salt,hydrate (1:3:6);Phosphinecarboxylic acid,dihydroxy-,oxide,trisodium salt,hexahydrate;Formic acid,phosphono-,trisodium salt,hexahydrate;Trisodium phosphonoformate hexahydrate
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CAS No:
Description
Phosphonoformic acid trisodium salt hexahydrate is white or almost white, crystalline powder.
Trisodium phosphonoformate hexahydrate is the hexahydrate form of trisodium phosphonoformate. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. It has a role as an antiviral drug. It is a hydrate and a one-carbon compound. It contains a trisodium phosphonoformate.|Foscarnet Sodium is the trisodium salt of a synthetic organic analogue of inorganic pyrophosphate with antiviral activity. Foscarnet selectively blocks the pyrophosphate binding site of herpesvirus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. This agent does not require phosphorylation by thymidine kinase (TK) or other kinases and therefore is active in vitro against herpes simplex virus (HSV) TK deficient mutants and cytomegalovirus (CMV) UL97 mutants. Because foscarnet crosses the blood brain barrier, it may be used in the treatment of viral infections of the CNS.|An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Trisodium phosphonoformate hexahydrate Basic Attributes
300.04
299.981018
964YS0OOG1
DTXSID3036991
C1193
29319090
Characteristics
109
-1.00200
490.7°C at 760 mmHg
250.6ºC
soluble in water.H2O: 0.1 g/mL hot, clear, colorless
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
SY8300000
Xi
P305 + P351 + P338
H315-H319-H335
|Warning|H315 (91.3%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)
Foscarnet
Computed Properties
Molecular Weight:300.04
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:11
Exact Mass:299.98103104
Monoisotopic Mass:299.98103104
Topological Polar Surface Area:109
Heavy Atom Count:16
Complexity:103
Covalently-Bonded Unit Count:10
Compound Is Canonicalized:Yes
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Trisodium phosphonoformate hexahydrate
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