Zinc fluorosilicate

207.47

205.896484

240-894-1

QTE5F70KZ7

2855

White crystalline powder

0

2.13790

White crystalline powder

2.104 g/cm³

50-70(分解)ºC

122 to 158 ° F

INDEX OF REFRACTION: 1.3824, 1.3956 /HEXAHYDRATE/

54.371 lb/100 lb water at 70 deg F

Oral-Rat LDL0: 100 mg/kg

Non-combustible; Zinc and fluoride fumes are emitted from the fire; react with acids to emit toxic hydrogen fluoride gas

PH OF 1% AQUEOUS SOLN 3.2; WHITE CRYSTALS /HEXAHYDRATE/|COLORLESS HEXAGONAL PRISMS; DECOMP @ 100 °C /HEXAHYDRATE/|HYDROLYZED BY ALKALI TO FLUORIDE ION /FLUOSILICATE SALTS/

Insoluble in water.

Salts, Basic

ZINC FLUOROSILICATE has weak oxidizing or reducing powers. Redox reactions can however still occur. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive.

III

6.1(b)

UN 2855 6.1/PG 3

3

22-34

26-36/37/39-45

C

The warehouse is ventilated, low-temperature and dry; stored and transported separately from food and acids

P260, P261, P264, P270, P271, P280, P301+P310, P304+P340, P305+P351+P338, P312, P314, P321, P330, P337+P313, P403+P233, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations January, 1990-June, 1998. Available from: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html as of November 2, 1998.|USEPA; Ambient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079|USEPA; Ambient Water Quality Criteria Doc: Zinc (1987) EPA 400/5-87-003|Arvidson, B. A Review of Axonal Transport of Metals. Toxicology 88: 1-14 (19994) Recent findings regarding axonal transport of metals, including zinc.|For more Special Reports (Complete) data for ZINC SILICOFLUORIDE (6 total), please visit the HSDB record page.

Special Hazards of Combustion Products: Toxic and irritating hydrogen fluoride and silicon tetrafluoride are formed in fires. (USCG, 1999)

|Warning|H302 (93.18%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 44 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P310, P304+P340, P305+P351+P338, P312, P314, P321, P330, P337+P313, P403+P233, P405, and P501

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Dust respirator; chemical goggles or face shield; protective gloves (USCG, 1999)|/NIOSH certified/ respirator; chemical goggles or face shield; protective gloves /Hexahydrate/|/NIOSH CERTIFIED RESPIRATOR/; GOGGLES OR FACE SHIELD; PROTECTIVE GLOVES. /HEXAHYDRATE/

Non-combustible

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.|Environmental considerations: Water spill: Neutralize with agricultural lime (slaked lime), crushed limestone, or sodium bicarbonate. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates or greater concentration.

If material not on fire and not involved in fire: Keep upwind. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.|/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.|/GUIDE 151: SUBSTANCES - TOXIC (Non-combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for ZINC SILICOFLUORIDE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

On the skin (and presumably in eyes and on mucous membranes), the fluorosilicates are irritants. /Fluorosilicate salts/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

highly

LD50 Oral Guinea pig 100 mg/kg

Patients with kidney dysfunction may be particularly susceptible to fluoride toxicity. /Fluoride/|Populations that appear to be at increased risk from the effects of fluoride are individuals that suffer from diabetes insipidus or some forms of renal impairment. /Fluoride/

Food and Environmental Agents: Effect on Breast-Feeding: Reported Sign or Symptom in Infant or Effect on Lactation: Fluorides: None. /from Table 7/

INGESTION OF AS LITTLE AS 9 MG/KG HAS CAUSED HUMAN DEATHS. /FLUORIDES/

IN TWO CASES /OF ZINC SILICOFLUORIDE INGESTION/ ... ANALYSIS SHOWED THAT THE CONCENTRATION OF ZINC WAS INCREASED OVER NORMAL VALUES MORE DEPENDABLY IN THE BLOOD THAN IN THE LIVER OR KIDNEYS. IN ... SUICIDE, THE CONCENTRATION OF ZINC IN THESE ORGANS WAS WITHIN THE RANGE OF NORMAL.|AFTER SUICIDE BY INGESTION OF LARGE AMT OF ZINC SILICOFLUORIDE (FLUATE), HIGH FLUORIDE ION CONCN WERE FOUND IN SUBJECTS' VOMITUS, STOMACH CONTENTS, DUODENUM & BLOOD (3200, 138, 16 & 1.7 MG/100 G, RESPECTIVELY). LIVER & KIDNEYS CONTAINED NORMAL FLUORIDE ION CONCN, INDICATING SHORT INTERVAL BETWEEN INTAKE & DEATH. MARKED DIFFERENCES WERE OBSERVED IN THE RATES OF ABSORPTION OF FLUORIDE ION AND ZINC ION FROM THE STOMACH AND THE FACT THAT ZINC ION HAS AN EMETIC EFFECT IN ORAL DOSES OF 250-500 MG. A LETHAL DOSE OF FLUORIDE ION MAY BE ABSORBED BEFORE VOMITING, WITHOUT AN INCREASE OF BLOOD ZINC ION.|/RENAL CLEARANCE/ 1. VIRTUALLY ALL FLUORIDE IN PLASMA ... IS ULTRAFILTERABLE. 2. RENAL EXCRETION OF RADIOFLUORIDE DEPENDS ON GLOMERULAR FILTRATION & VARIABLE TUBULAR REABSORPTION. 3. PROBABLY, REABSORPTION IS LARGELY PASSIVE ... 4. FLUORIDE EXCRETION INCR WHEN PLASMA CONCN IS INCREASED. 5. PROCEDURES THAT INCREASE URINARY FLOW RATE (EG, ADMIN OF OSMOTIC DIURETICS, HYPERTONIC SALINE, OR DIURETIC DRUGS) INCREASE THE CLEARANCE OF FLUORIDE. /FLUORIDE/|IN FEMALE RATS, THE SKELETONS OF YOUNGER RATS APPARENTLY ARE MORE EFFICIENT AT REMOVING FLUORIDE FROM CIRCULATION THAN ARE THOSE OF OLDER RATS. /SODIUM FLUORIDE/|For more Absorption, Distribution and Excretion (Complete) data for ZINC SILICOFLUORIDE (6 total), please visit the HSDB record page.

INHIBITION OF ONE OR MORE ENZYMES CONTROLLING CELLULAR GLYCOLYSIS (& PERHAPS RESP) MAY RESULT IN A CRITICAL LESION. ... BINDING OR PRECIPITATION OF CALCIUM AS CALCIUM FLUORIDE ... SUGGESTED AS MECHANISM UNDERLYING MANY DIVERSE SIGNS & SYMPTOMS IN FLUORIDE POISONING, PARTICULARLY IF DEATH IS DELAYED. ... AT LEAST IN SOME SPECIES FLUORIDE INTERFERES WITH BOTH CONTRACTILE POWER OF HEART AND THE MECHANISM OF BEAT IN A WAY THAT CANNOT BE ASCRIBED TO HYPOCALCEMIA. /FLUORIDE/|... Floride interacts with bones and teeth by replacing hydroxyl or bicarbonate ions in hydroxyapatite to form fluorohydroxyapatite. ... The presence of fluorohydroxyapatite increases the crystalline structure of the bone and reduces its solubility. ... Dental fluorosis results from toxic effects of fluoride on the epithelial enamel organ. /Fluoride/|In acute poisoning, fluoride kills by blocking normal cellular metabolism. Fluoride inhibits enzymes, in particular metalloenzymes involved in essential processes, causing vital functions such as the initiation and transmission of nerve impulses, to cease. ... /Fluoride/

Inhalation of dust irritates nose and throat; excessive inhalation may cause severe pulmonary inflammation. Ingestion causes nausea, cramps, vomiting, shock, convulsions, cyanosis, and other symptoms of fluoride poisoning. Contact with eyes or skin causes irritation; skin ulcers may develop. (USCG, 1999)

INHALATION: move to fresh air. INGESTION: cause vomiting by giving soapy water or mustard water; have patient drink large quantities of lime water, if necessary, give stimulant such as strong coffee. EYES: flush with water; call physician as necessary. SKIN: wash with soap and water. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Fluorine and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's to support vital signs if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Fluorine and related compounds/

A suicide served to show that poisoning by zinc hexafluorosilicate is typical of poisoning by the fluoride ion. A 35 year old man drank half a glassful of a 5 to 10% solution of a commercial formulation. Following ingestion, emesis and tetanic convulsions occurred in 3.4 hr and death in 4.5 hr. Pathology was typical of fluoride poisoning.|Inhalation of dust irritates nose and throat; excessive inhalation may cause severe pulmonary inflammation. Ingestion cause nausea, cramps, vomiting, shock, convulsions, cyanosis, and other symptoms of fluoride poisoning. Contact with eyes or skin causes irritation; skin ulcers may develop.|SYMPTOMATOLOGY: 1. Severe gastritis or gastroenteritis with abdominal pain, retching, and prolonged vomiting, beginning 10-60 min after ingestion. Vomitus may become bloody. Diarrhea is sometimes violent; the feces are watery and later tarry. Dehydration becomes intense. 2. Shock, pallor, cyanosis and coldness. Rapid, weak or imperceptible pulse, low blood pressure, rapid and shallow respirations. 3. Sometimes breathing is deep and rapid, reflecting an accompanying metabolic acidosis. 4. Drowsiness, hyporeflexia, dilated pupils, coma. Vasomotor instability, shock or coma and a serum iron level in great excess of the total iron-binding capacity are poor prognostic signs. /Fluoride/|SYMPTOMATOLOGY: 5. Liver injury, consisting of hemorrhagic necrosis which is usually reversible. 6. Death from shock, usually in 4-5 hr. Sometimes following apparent recovery, pneumonia with fever or secondary shock may cause death 1-3 days later. 7. Among survivors pyloric stenosis and mild hepatic cirrhosis may be encountered as persistent sequelae, but recovery is usually complete. /Fluoride/|For more Human Toxicity Excerpts (Complete) data for ZINC SILICOFLUORIDE (11 total), please visit the HSDB record page.

Silicate(2-), hexafluoro-, zinc (1:1): ACTIVE|The use of fluoride-containing compositions for the removal of pollutants from wastewater is described.|A liquid composition containing one or more fluoro-complex salts for the rapid setting of dental cements is given.