ENDOTHELIN 1 HUMAN, PORCINE
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ENDOTHELIN 1 HUMAN, PORCINE
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CAS No:
117399-94-7
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Formula:
C109H159N25O32S5
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Chemical Name:
ENDOTHELIN 1 HUMAN, PORCINE
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Synonyms:
ET-1;ET-1, HUMAN;ET-1, HUMAN AND PORCINE;ET-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT);ET-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG);ET-1, HUMAN, PORCINE;ET-1 (HUMAN, PORCINE, DOG, RAT);ENDOTHELIN-I, HUMAN, PORCINE
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CAS No:
Description
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Characteristics
1035.13000
-0.36
white powder
1.273±0.06 g/cm3(Predicted)
2467.3±65.0 °C(Predicted)
1446.0±34.3 °C
1.556
soluble in water.1% acetic acid: >1 mg/mL
−20°C
ENDOTHELIN 1 HUMAN, PORCINE Use and Manufacturing
Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors
Computed Properties
Molecular Weight:2491.9
XLogP3:-3.7
Hydrogen Bond Donor Count:32
Hydrogen Bond Acceptor Count:40
Rotatable Bond Count:47
Exact Mass:2491.0220087
Monoisotopic Mass:2490.0186539
Topological Polar Surface Area:1040
Heavy Atom Count:171
Complexity:5300
Defined Atom Stereocenter Count:23
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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