FMOC-L-ALANINOL
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FMOC-L-ALANINOL
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CAS No:
161529-13-1
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Formula:
C18H19NO3
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Chemical Name:
FMOC-L-ALANINOL
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Synonyms:
FMOC-(S)-2-AMINO-1-PROPANOL;FMOC-ALA-OL;FMOC-ALANINOL;FMOC-L-ALANINOL;N-FMOC-L-ALANINOL;N-ALPHA-FMOC-L-ALANINOL;N-(9-FLUORENYLMETHOXYCARBONYL)-L-ALANINOL;Fmoc-DL-Alaninol
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CAS No:
Characteristics
58.6
2.8
Solid
1.210±0.06 g/cm3(Predicted)
120 °C
503.9±33.0 °C(Predicted)
258.5ºC
1.598
-15°C
5.66E-11mmHg at 25°C
FMOC-L-ALANINOL Use and Manufacturing
General procedure: To a solution of carboxylic acid (10 mmol) in THF (10 mL), DIPEA (11 mmol, 1.42 mL) and 50percent T3P in EtOAc (20 mmol, 6.36 mL) were added at 0 °C and the solution was stirred for about 10 min. Then aqueous solution of NaBHTo an ice cold solution of Fmoc-Ala-OH (1 mmol) and DIPEA (1.2 mmol) in DMF (5 mL) at 0 °C, COMU (1.1 mmol) was added. To a mixture of (S)-2-aminopropan-l-ol (2 g, 26.6 mmol) and NaGeneral procedure: Suitable N-protected amino alcohols (e.g. Fmoc and boc) can be obtained by reacting an amino alcohol with a desired protecting group precursor that protects the amine group with the desired protecting group Pgi . For example, N-Fmoc protected amino alcohols were prepared (in an Erlenmeyer flask) by suspending/dissolving Fmoc-O-Su in acetone (in a ratio of about 2.5-6 mL acetone per mmol of Fmoc-O-Su) with stirring. To this briskly stirring solution was added dropwise a solution of the amino alcohol (in a ratio of about 1 to 1 .2 eq. per mmol of Fmoc-O-Su) dissolved in acetone (in a ratio of about 0.4- 1 .2 mL acetone per mmol of the amino alcohol) and occasionally some water if the amino alcohol is not completely soluble in the acetone alone. When addition was complete, a solution containing NaHC0
Computed Properties
Molecular Weight:297.3
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:297.13649347
Monoisotopic Mass:297.13649347
Topological Polar Surface Area:58.6
Heavy Atom Count:22
Complexity:365
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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