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2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid

2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid structure

CAS No:
67776-06-1
Formula:
C7H12N2O4S
Chemical Name:
2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid
Synonyms:
N-(ACETYLOXY)-3-NITROSOTHIOVALINE;SNAP;(+/-)-S-NITROSO-N-ACETYLPENICILLAMINE;S-NITROSO-N-ACETYL-D,L-PENICILLAMINE;S-Nitroso-N-acetyl-DL-penicillamine,N-Acetyl-3-(nitrosothio)-DL-valine, S-Nitroso-N-acetylpenicillamine, SNAP;(R)-2-acetaMido-3-Methyl-3-(nitrosothio)butanoic acid;SNAP [S-Nitroso-N-acetylpenicillaMine];Anti-SNAP25, C-Terminal antibody produced in rabbit
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation[1][2][3][4].

A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.

SNAP is an S-nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content. At pH 6-8 and 37°C, the half-life of SNAP is approximately six hours in the presence of transition metal ion chelators.

2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid is green crystalline solid

2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid Basic Attributes

Molecular Weight：

220.25

Exact Mass：

220.25

NSC Number：

312630

Color/Form：

green

Characteristics

PSA：

121

XLogP3：

1.13

Appearance：

green powder

Density：

1.4261 (rough estimate)

Melting Point：

150.5°C

Refractive Index：

1.5400 (estimate)

Water Solubility：

H2O: ≥2mg/mLDMSO: ≥20mg/mL, clear (faint green to very dark green)

Storage Conditions：

−20°C

PKA：

3.06±0.10(Predicted)

Critical Temperature & Pressure：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

26-36

RTECS Number：

YV9383000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

36/37/38

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

N-Acetyl-S-Nitrosopenicillamine

2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid Use and Manufacturing

Produced concentration-related relaxations of mouse anococcygeus, in a range similar to that already found for NO and other nitrovasodilators. A potent relaxant of non-vascular smooth muscle. Serves as an NO donor.

Computed Properties

Molecular Weight:220.25
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:220.05177804
Monoisotopic Mass:220.05177804
Topological Polar Surface Area:121
Heavy Atom Count:14
Complexity:254
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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S-Nitroso-N-acetyl-DL-penicillamine

CAS No.: 67776-06-1

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Guide of 2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid

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