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Fmoc-3-(4-pyridyl)-L-alanine

Fmoc-3-(4-pyridyl)-L-alanine structure

CAS No:
169555-95-7
Formula:
C23H20N2O4
Chemical Name:
Fmoc-3-(4-pyridyl)-L-alanine
Synonyms:
FMOC-(S)-2-AMINO-3-(4'-PYRIDYL)PROPANOIC ACID;FMOC-L-4PAL-OH;FMOC-L-4-PYRIDYLALANINE;FMOC-L-4-PAL;FMOC-BETA-(4-PYRIDYL)-L-ALANINE;Fmoc-beta-(4-pyridyl)-Ala-OH;Fmoc-L-4-Pyridylala;Fmoc-L-3-(4-Pyridyl)-alanine
Categories:
Biochemical Engineering > Amino Acids and Derivatives

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Description

Light yellow powder

Fmoc-3-(4-pyridyl)-L-alanine Basic Attributes

Molecular Weight：

388.42

Exact Mass：

388.142303

DSSTox ID：

DTXSID10359652

HScode：

29333990

Characteristics

PSA：

88.5

XLogP3：

3.6

Density：

1.309±0.06 g/cm3(Predicted)

Boiling Point：

646.9±55.0 °C(Predicted)

Flash Point：

345.0±31.5 °C

Refractive Index：

1.637

Water Solubility：

Soluble in 0.1g in 4mL DMF(clearly soluble).

Storage Conditions：

2-8°C

Vapor Pressure：

1.28E-17mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fmoc-3-(4-pyridyl)-L-alanine Use and Manufacturing

General procedure: Peptides were synthesized using a solid phase peptide synthesis protocol using an Aapptec FocusXC automated peptide synthesizer coupled with a heating system using the Fmoc chemistry andWang resin as solid support [34]. To prepare the resin for synthesis, a reaction vessel equipped with asintered glass bottom was charged with Fmoc-Leu-Wang resin (0.2 mM), and swelled in a mixture ofdichloromethane and DMF (1:1) for 15 min. The resin was then transferred to a peptide synthesizerreaction vessel. The resin was deprotected twice using 20% piperidine in DMF for 5 min at 70 C.Subsequently, an Fmoc-protected amino acid was double coupled with the Leucine-wang resin bytreating with N, N'-diisopropylcarbodiimide (3.0 equiv., 0.2 M in DMF) and Oxyma (3.0 equiv., 0.2 M inDMF) at 70 C for 8 min. Completion of coupling reactions was monitored by a Kaiser's test for theinitial peptide [40]. Each coupling was followed by removal of the Fmoc group using 20% piperidinein DMF at 70 C for 5 min and repeated once. The cycle of the Fmoc removal and coupling wasrepeated with subsequent Fmoc-protected amino acids to generate the desired resin-bound peptide.Cleavage of the peptide from resin and concomitant deprotection of the side chain protecting groupswas carried out by shaking in TFA/triisopropylsilane/H20 (95/2.5/2.5; 5 mL), at ambient temperature for3 h. Subsequent filtration aorded the peptide in the filtrate and the volume was reduced to 0.2 mL.Then, the crude peptides were precipitated by adding cold diethyl ether, and the crude peptides werethen purified by RP-HPLC. Synthesized peptides were characterized by NMR, and the high-resolutionmass spectroscopy.

Computed Properties

Molecular Weight:388.4
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:388.14230712
Monoisotopic Mass:388.14230712
Topological Polar Surface Area:88.5
Heavy Atom Count:29
Complexity:555
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Fmoc-3-(4-pyridyl)-L-alanine

Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic Acid

Fmoc-3-(4-pyridyl)-L-alanine 169555-95-7

CAS No.: 169555-95-7

Grade: Pharmaceutical Grade

Content: 99%

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Hangzhou Go Top Peptide Biotech Co.,Ltd. Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of Pharmaceutical Peptide,Cosmetic peptide,Custom peptides,API polypeptide,Amino acids and derivatives

Boc-N-Me-Ala-OH

CAS No.: 169555-95-7

Grade: Research and Industrial Grade

Content: 98.00%

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Guide of Fmoc-3-(4-pyridyl)-L-alanine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Fmoc-3-(4-pyridyl)-L-alanine

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