Thymosin alpha 1
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Thymosin alpha 1
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CAS No:
62304-98-7
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Formula:
C129H215N33O55
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Chemical Name:
Thymosin alpha 1
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Synonyms:
Thymosin α1 Acetate;Thymosin α 1 Acetate(Thymalfasin);Thymosina1Acetate;thymosin α1 bovine;Thymosinα1 bovine,Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn;ThyMosins alpha 1;Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH acetate salt;Thymosin α1, Thymalfasin
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CAS No:
Description
Thymalfasin is an immunomodulating agent able to enhance the Thl immune response. Sequence: N-acetyl-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn.
Thymalfasin is a polypeptide.|Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity. (NCI04)|A thymus hormone polypeptide found in thymosin fraction 5 (a crude thymus gland extract) but now produced by synthesis. It is used alone or with interferon as an immunomodulator for the treatment of CHRONIC HEPATITIS B and HEPATITIS C. Thymalfasin is also used for the treatment of chemotherapy-induced immunosuppression, and to enhance the efficacy of influenza and hepatitis B vaccines in immunocompromised patients.
Characteristics
1460
-9.87
White powder
1.4±0.1 g/cm3
2899.7±65.0 °C at 760 mmHg
1707.5±34.3 °C
1.563
−20°C
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)
alpha1 Thymosin
Thymosin alpha 1 Use and Manufacturing
Zadax- in (SciClone).
Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:3108.3
XLogP3:-24
Hydrogen Bond Donor Count:49
Hydrogen Bond Acceptor Count:59
Rotatable Bond Count:111
Exact Mass:3107.5074829
Monoisotopic Mass:3106.5041281
Topological Polar Surface Area:1460
Heavy Atom Count:217
Complexity:7190
Defined Atom Stereocenter Count:32
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It promotes the maturation of peripheral blood lymphocytes after mitogen activation, increases the secretion of various lymphokines such as interferon a, g, interleukin 2 and interleukin 3 produced by T cells after activation by various antigens or mitogens, and increases the level of lymphokine receptors on T cells. It also enhances allogeneic and autologous human mixed lymphocyte reactions by activating T4 cells (helper/inducer). It may affect the recruitment of NK precursor cells, which become more cytotoxic after exposure to interferon. In vivo, it can enhance the secretion of interleukin 2 and the expression of interleukin 2 receptor by mouse lymphocytes activated by concanavalin A.
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