Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
-
![Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/c1b2190fc13b41e8b879139635ca8ba3.png "Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)")
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
structure -
-
CAS No:
371945-06-1
-
Formula:
C10H10N2O3
-
Chemical Name:
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
-
Synonyms:
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI);Furo[2,3-b]pyridine-2-carboxylicacid,3-amino-, ethyl ester;ethyl 3-amino furo[2,3-b]pyridine-2-carboxylate;3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester;3-aminofuro[2,3-b]pyridine-2-carboxylate;Ethyl 3-aminofuro[2,3-B]pyridine-2-carboxylate ,98%;ethyl 2-aminofuro[2,3-b]pyridine-3-carboxylate
- Categories:
-
CAS No:
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Basic Attributes
206.198
206.06900
DTXSID10612693
2934999090
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Use and Manufacturing
To a stirred mixture of the pyridine 51a (2.00 g, 1.0 eq), the alcohol 51b (1.43 mL, 1.05 eq), CuI (0.05 g, 0.02 eq) is added Cs2- Chloro 3-pyridine carbonitrile (1, 2.0 g, 1 equiv.), Cs2C03 (14.2 g, 3 equiv.) and ethyl glycolate (1.5 mL, 1.2 equiv.) were placed in a flask under inert atmosphere. Dry toluene and DBU (4.3 mL, 2 equiv) were added and the suspension was heated at 80 °C for 24 h with vigorous stirring. The reaction mixture was cooled to RT, and then water and EtOAc were added. The organic layer was seperated and was washed with water before being dried over anhydrous Na2S04 and concentrated in vacuo. Purification was done by column chromatography on silica gel using 10-40percent EtOAC: hexane as a mobile phase to get product 2 (1.5 g, 50percent) as a white solid. *H NMR (CDC13, 400 MHz): δ 8.51 (dd, / = 5.0, 2.0 Hz, 1H), 7.96 (dd, / = 8.0, 2.0 Hz, 1H), 7.23-7.28 (m, 1H), 4.44 (q, / = 7.0 Hz, 2H), 4.01 (br, s, 2H), 1.44 (t, / = 7.0 Hz, 3H); ESI-MS: nt/z 229.05 [M+Na]+2-Chloro-3-pyridinecarbonitrile, 1 , (4.0Og, 28.9mmol), Cs
Computed Properties
Molecular Weight:206.20
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:206.06914219
Monoisotopic Mass:206.06914219
Topological Polar Surface Area:78.4
Heavy Atom Count:15
Complexity:247
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
-
InquiryCAS No.: 371945-06-1Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
Cyclohexanecarboxylic acid, 1,3,4,5-tetrahydroxy-, ethyl ester, (1alpha,3R,4alpha,5R)- (9CI)
463325-95-3
-
Cyclopropanecarboxylic acid, 1-formyl-2-methyl-, ethyl ester (9CI)
260261-27-6
-
Cyclopentanecarboxylic acid, 2-(hydroxyimino)-, methyl ester (9CI)
170016-09-8
-
Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, ethyl ester, (1R,2R)-rel- (9CI) Formula
669058-57-5
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, (1R,2S)-rel- (9CI) Formula
213316-32-6
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI) Formula
681807-60-3
-
3-Cyclopentene-1-carboxylic acid, 1-(chlorocarbonyl)-, ethyl ester (9CI) Structure
76910-09-3
-
Cyclopropanecarboxylic acid, 2-propyl-, ethyl ester, (1R,2S)- (9CI) Structure
492468-18-5
-
What is Cyclopentanecarboxylic acid, 2-(formylhydrazono)-, ethyl ester, (Z)- (9CI)
163352-99-6
-
What is D-glycero-D-gulo-Heptonic acid, 5-amino-2,6-anhydro-5-deoxy-, methyl ester (9CI)
761345-72-6
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
SDSRequest for Quotation