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3-Amino-2-naphthoic acid

3-Amino-2-naphthoic acid structure

CAS No:
5959-52-4
Formula:
C11H9NO2
Chemical Name:
3-Amino-2-naphthoic acid
Synonyms:
2-Naphthalenecarboxylic acid,3-amino-;2-Naphthoic acid,3-amino-;3-Amino-2-naphthalenecarboxylic acid;3-Amino-2-naphthoic acid;2-Amino-3-naphthoic acid;2-Amino-3-carboxynaphthalene;β-Naphthylamine-3-carboxylic acid;2-Aminonaphthalene-3-carboxylic acid;NSC 37061
Categories:
Biochemical Engineering > Amino Acids and Derivatives

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Description

yellow-green to green powder

3-amino-2-naphthoic acid is a naphthoic acid.

3-Amino-2-naphthoic acid Basic Attributes

Molecular Weight：

187.19

Exact Mass：

187.19

BRN：

744099

EC Number：

227-726-2

UNII：

IV5Z0PHL5D

NSC Number：

37061

DSSTox ID：

DTXSID8064066

HScode：

2922499990

Characteristics

PSA：

63.3

XLogP3：

2.6

Appearance：

Yellow-green to green Powder

Density：

1.352 g/cm3

Melting Point：

216.5 °C

Boiling Point：

384.9°C at 760 mmHg

Flash Point：

186.6ºC

Water Solubility：

soluble in alcohol and ether. Insoluble in water.

Storage Conditions：

Store in a cool, dry place. Store in a tightly closed container.

Toxicity：

Oral-Mouse LD50: 1600 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36-24/25

RTECS Number：

QL1400000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately

3-Amino-2-naphthoic acid Use and Manufacturing

Methods of Manufacturing

Under the condition of a catalyst, it is prepared by co-heating 3-hydroxy-2-naphthoic acid and ammonia. Add 28% ammonia, zinc chloride and 3-hydroxy-2-naphthoic acid to the autoclave in sequence, stir, heat for 3 hours to bring the temperature to 195°C, keep it for 36 hours, and keep the pressure at about 2.7MPa. Cool to room temperature, then add concentrated hydrochloric acid to the reaction mixture, boil the suspension for 30 min, and filter while hot. Mix the filter cake with water and hydrochloric acid, boil for 30 minutes, and filter. After the two filtrates were cooled, 3-amino-2-naphthoate was precipitated and filtered. The filtrate was heated to 85°C, salt was added, and cooling was continued to obtain the second batch of hydrochloride. Then add 40% sodium hydroxide solution to make it alkaline, heat the mixture to 85°C, add concentrated hydrochloric acid, until the Congo red test paper is acidic, stir, and then add an appropriate amount of 10% sodium acetate solution to make the Congo red test paper not blue. Wash with hot water and press dry to get the finished product.

Uses

Organic synthesis, dye intermediate.

Manufacturing Info：

2-Naphthalenecarboxylic acid, 3-amino-: INACTIVE

Computed Properties

Molecular Weight:187.19
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:187.063328530
Monoisotopic Mass:187.063328530
Topological Polar Surface Area:63.3
Heavy Atom Count:14
Complexity:229
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Zinc chloride

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3-Amino-2-naphthoic acid

CAS No.: 5959-52-4

Content: 99.00%

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CAS No.: 5959-52-4

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Guide of 3-Amino-2-naphthoic acid

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
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3-Amino-2-naphthoic acid

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