Arginine hydrochloride
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Arginine hydrochloride
structure -
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CAS No:
15595-35-4
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Formula:
C6H14N4O2.xClH
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Chemical Name:
Arginine hydrochloride
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Synonyms:
L-Arginine,hydrochloride (1:?);Arginine,hydrochloride,L-;L-Arginine,hydrochloride;Arginine hydrochloride;Arginine chlorhydrate;Arginine muriate;Argi-U
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CAS No:
Description
Arginine hydrochloride is a L-alpha-amino acid.|Arginine Hydrochloride is the hydrochloride salt form of arginine, an essential amino acid in juvenile humans. Arginine is a complex amino acid, often found at active sites in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04)|An essential amino acid that is physiologically active in the L-form.
Arginine hydrochloride Basic Attributes
210.66
210.088348
214-275-1
F7LTH1E20Y
C29606
V03AF11|B - Blood and blood forming organs
2922499990
Safety Information
S24/25
CF1995500
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362
H315
|Warning|H315 (98.45%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 339 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
LysaKare is indicated for reduction of renal radiation exposure during Peptide-Receptor Radionuclide Therapy (PRRT) with lutetium (177Lu) oxodotreotide in adults.
Arginine
Arginine hydrochloride Use and Manufacturing
It is obtained from gelatin as raw material, after acid hydrolysis, and then separation and purification. Gelatin [HCl, (hydrolysis)]→[116-122℃, 16h] hydrolyzate [decompression]→[(concentration)] concentrate [NaOH(neutralization)]→[pH 10.5-11] neutralization liquid [condensation ]→[pH8]benzylidene arginine crude product [HCl(hydrolysis)]→[boiling] hydrolysate[activated carbon(decolorization)]→decolorization liquid[303×2 resin (adsorption)]→[pH7-8] filtrate [HCl(acidification)]→[pH3-3.5] acidification solution [concentration, crystallization]→L-arginine hydrochloride benzyl arginine crude preparation Put gelatin and 2 times the amount of industrial hydrochloric acid into the hydrolysis tank Inside, heat at 116-122℃ and reflux for 16h to obtain hydrolysate. When concentrated under reduced pressure to 1/2 volume, add distilled water to dilute to the original volume, and then concentrate to obtain a concentrated solution. After cooling, slowly add 30% NaOH solution, keep stirring, and keep the temperature below 10℃, adjust the pH to 10.5-11, and then slowly add benzaldehyde dropwise. When the pH is 8, stop the benzaldehyde addition and stir. After reacting for 0.5h to complete the reaction, the benzylidene arginine crystallized out. After standing for 6 hours, it was filtered, the crystals were taken and washed with water, filtered, dried, pulverized, and dried at 60° C. to obtain crude benzylidene arginine. The crude product is hydrolyzed and separated and purified. Add 0.8 times the amount of 6mol/L hydrochloric acid to the crude product of benzylidene arginine, heat and boil for 50 minutes for acid hydrolysis. When hydrolyzed to 40 minutes, add a small amount of activated carbon to decolor, filter, and filter the residue with hot water Wash, filter again, combine the washing liquid, stand still for layering. Separate the upper layer of benzaldehyde solution to be recovered, and add the treated weakly basic styrene anion resin 303×2 to the lower layer of aqueous solution for adsorption until pH 7-8 (about 3h), filter out the resin, and collect the filtrate . Add 6mol/L HCl to acidify the collected filtrate to adjust the pH to 3-3.5, add an appropriate amount of activated carbon, heat and stir for 10 min, filter the filtrate and then keep it on a water bath at 80-90°C under reduced pressure and concentrate until a small amount of crystals are precipitated, stop Concentrate under reduced pressure, cool to crystallize, filter and take the crystals, wash with 70% ethanol, then with 95% ethanol, filter and dry at 80°C to obtain refined L-arginine hydrochloride. The total yield is about 4.5%.
Used as pharmaceutical raw materials and food additives
Laboratory chemicals
Non-TSCA use
Pharmaceutical and medicine manufacturing|L-Arginine, hydrochloride (1:1): ACTIVE
Human drugs -> LysaKare -> EMA Drug Category|Detoxifying agents for antineoplastic treatment -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Skin conditioning
Computed Properties
Molecular Weight:210.66
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:210.0883534
Monoisotopic Mass:210.0883534
Topological Polar Surface Area:128
Heavy Atom Count:13
Complexity:176
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
The basic unit for synthesizing proteins, enhancing the body's defense function and improving the body's cellular immune function
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