Dithioerythritol
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Dithioerythritol
structure -
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CAS No:
6892-68-8
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Formula:
C4H10O2S2
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Chemical Name:
Dithioerythritol
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Synonyms:
2,3-Butanediol,1,4-dimercapto-,(2R,3S)-rel-;Erythritol,1,4-dithio-;2,3-Butanediol,1,4-dimercapto-,(R*,S*)-;rel-(2R,3S)-1,4-Dimercapto-2,3-butanediol;1,4-Dithioerythritol;Dithioerythritol;DTE;erythro-1,4,-Dimercapto-2,3-butanediol;1451214-85-9
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CAS No:
Description
DTE (Dithioerythritol) is a sulfur containing sugar derived from the corresponding 4-carbon monosaccharide erythrose; is an epimer of dithiothreitol(DTT).
Dithioerythritol is the meso-diastereomer of 1,4-dimercaptobutane-2,3-diol; a sulfur-containing sugar derived from the monosaccharide erythrose; and an epimer of dithiothreitol. It has a role as a reducing agent.|A compound that, along with its isomer, Cleland's reagent (DITHIOTHREITOL), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups.
Characteristics
42.5
0.07
White to pale yellow or beige Powder
1.3±0.1 g/cm3
83 °C
364.5±42.0 °C at 760 mmHg
174.2±27.9 °C
1.579
H2O: 10 mg/mL, clear, colorless
2-8°C
Safety Information
9
UN 3335
3
36/37/38-22
26-36-37/39
KF2410000
Xi,Xn
Stable. Combustible. Incompatible with strong oxidizing agents.
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 87 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Chemical agents that react with SH groups. This is a chemically diverse group that is used for a variety of purposes. Among these are enzyme inhibition, enzyme reactivation or protection, and labelling. (See all compounds classified as Sulfhydryl Reagents.)
2,3-Dihydroxy-1,4-dithiolbutane
Dithioerythritol Use and Manufacturing
Reagent for the reduction of disulfide group. Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis. Cleavage of disulfide bonds in proteins
2,3-Butanediol, 1,4-dimercapto-, (2R,3S)-rel-: ACTIVE
Computed Properties
Molecular Weight:154.3
XLogP3:-0.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:154.01222190
Monoisotopic Mass:154.01222190
Topological Polar Surface Area:42.5
Heavy Atom Count:8
Complexity:52
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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