NG-Monomethyl-L-arginine
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NG-Monomethyl-L-arginine
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CAS No:
17035-90-4
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Formula:
C7H16N4O2
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Chemical Name:
NG-Monomethyl-L-arginine
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Synonyms:
L-Ornithine,N5-[imino(methylamino)methyl]-;Ornithine,N5-(methylamidino)-,L-;N5-[Imino(methylamino)methyl]-L-ornithine;ω-N-Monomethylarginine;NG-Methylarginine;N5-(Methylamidino)-L-ornithine;ω-N-Methylarginine;Methylarginine;NG-Monomethylarginine;L-NG-Methylarginine;L-NMA;NG-Methyl-L-arginine;NG-Monomethyl-L-arginine;L-NMMA;L-Monomethylarginine;NG-methyl-L-arginine;Tilarginine;ω-N-Monomethyl-L-arginine;42342-68-7;852173-78-5
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CAS No:
Description
mp 180-190°C[a]D 10.5° (c=4, water)
N(omega)-methyl-L-arginine is a L-arginine derivative with a N(omega)-methyl substituent. It is a member of guanidines, a non-proteinogenic L-alpha-amino acid and a L-arginine derivative. It is a conjugate acid of a N(omega)-methyl-L-argininate. It is a tautomer of a N(omega)-methyl-L-arginine zwitterion.|Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.|Tilarginine is a pan-nitric oxide synthase (NOS) inhibitor, with potential immunomodulating and antineoplastic activities. Upon administration, tilarginine binds to and inhibits NOS, a free radical signaling molecule that promotes angiogenesis, metastasis, and immunosuppression in the tumor microenvironment (TME). Reduction in NOS activity may abrogate the immunosuppressive TME, enhance tumor antigen-specific immune response and inhibit tumor cell proliferation.|A competitive inhibitor of nitric oxide synthetase.
NG-Monomethyl-L-arginine Basic Attributes
188.231
188.23
27JT06E6GR
DTXSID3040560|DTXSID70872413|DTXSID20166117
C1178
Characteristics
114
0.59500
1.32±0.1 g/cm3(Predicted)
341.0±52.0 °C(Predicted)
191.3ºC
D25 +26° (c = 1 in 1N HCl)
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Arginine, L-NG-Monomethyl
Computed Properties
Molecular Weight:188.23
XLogP3:-4.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:188.12732577
Monoisotopic Mass:188.12732577
Topological Polar Surface Area:114
Heavy Atom Count:13
Complexity:193
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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