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N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester

N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester structure

CAS No:
24277-39-2
Formula:
C14H25NO6
Chemical Name:
N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester
Synonyms:
L-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-,1-(1,1-dimethylethyl) ester;Glutamic acid,N-carboxy-,N,1-di-tert-butyl ester,L-;N-tert-Butoxycarbonylglutamic acid α-tert-butyl ester;NSC 164659;N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester;639: PN: WO2006034056 TABLE: 10 claimed protein;(4S)-5-tert-Butoxy-4-[(tert-butoxycarbonyl)amino]-5-oxopentanoic acid;BOC-L-glutamic acid tert-butyl ester;N-α-tert-Butoxycarbonyl-L-glutamic acid α-tert butyl ester;(S)-5-tert-Butoxy-4-(tert-butoxycarbonylamino)-5-oxopentanoic acid;N-Boc-glutamic acid tert-butyl ester;(S)-2-[(tert-Butoxycarbonyl)amino]pentanedioic acid 1-tert-butyl ester;Boc-L-glutamic acid 1-tert-butyl ester;(4S)-5-(tert-Butoxy)-4-[[(tert-butoxy)carbonyl]amino]-5-oxopentanoic acid;(4S)-5-[(2-Methylpropan-2-yl)oxy]-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid;500297-64-3
Categories:
Biochemical Engineering > Amino Acids and Derivatives

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Description

White powder crystal

N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester Basic Attributes

Molecular Weight：

303.35

Exact Mass：

303.35

NSC Number：

164659

HScode：

29241900

Characteristics

PSA：

102

XLogP3：

1.7

Density：

1.1±0.1 g/cm3

Melting Point：

103.3-105.5 °C

Boiling Point：

449.8°C at 760 mmHg

Flash Point：

225.8±27.3 °C

Refractive Index：

1.470

Water Solubility：

soluble in dimethyl formamide.

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22/22-36/37/38

safety instructions：

4-7-28-35-44

N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester Use and Manufacturing

Solution of crude N-Boc-Glutamic acid 1-tert-butyl ester, 5-methyl ester from the previous step (30.4 g, 95.8 mmol) in THF (300 mL) was mixed with 144 mL of IN LiOH. After 40 minutes of stirring, TLC showed absence of starting material. THF was removed on a roto-vap. Aqueous solution was extracted with AcOEt (3×100 mL) and acidified to pH 4 with solid citric acid. The mixture was extracted again with AcOEt (3×100 mL). Acetate extracts from acidic extraction were combined, washed with brine (2×50 mL), dried (MgSOGeneral procedure: 0.2 N solution of LiOH (38 mL, 7.6 mmol) was added to a solution of 6.9 mmol of N-Boc-diester 10 or 11 in 38 mL of THF cooled to 0 °C. The mixture was stirred at 0 °C for 30 min, then for 20 h at room temperature. The solution was evaporated by half, 20 mL of 5 percent aqueous solution of NaHCO

Computed Properties

Molecular Weight:303.35
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:303.16818752
Monoisotopic Mass:303.16818752
Topological Polar Surface Area:102
Heavy Atom Count:21
Complexity:391
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 24277-39-2

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Content: 98.00%

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Boc-L-glutamic acid 1-tert-butyl ester

CAS No.: 24277-39-2

Content: 99.00%

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Guide of N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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N-(tert-Butoxycarbonyl)-L-glutamic acid 1-tert-butyl ester

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