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Lisdexamfetamine dimesylate

Lisdexamfetamine dimesylate structure

CAS No:
608137-33-3
Formula:
C15H25N3O.2CH4O3S
Chemical Name:
Lisdexamfetamine dimesylate
Synonyms:
Hexanamide,2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-,(2S)-,methanesulfonate (1:2);Hexanamide,2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-,(2S)-,dimethanesulfonate;NRP 104;Lisdexamfetamine dimesylate;Vyvanse;SPD 489;N-(L-Lysyl)-D-amphetamine dimesylate;Lisdexamphetamine dimesylate
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

Vyvanse is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|Lisdexamfetamine Dimesylate is the dimesylate form and prodrug of the d-isomer of amphetamine, a non-catecholamine sympathomimetic amine with central nervous system (CNS) stimulating activity. Upon administration, lisdexamphetamine is converted to dextroamphetamine through cleavage of the lysine group. Dextroamphetamine acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from its storage sites in nerve terminals in the CNS, and inhibits their uptake within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria, mental alertness and excitement and appetite suppression. As a CNS stimulant, this agent may increase blood pressure.|A dextroamphetamine drug precursor that also functions as a CENTRAL NERVOUS SYSTEM STIMULANT and DOPAMINE UPTAKE INHIBITOR and is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.

Lisdexamfetamine dimesylate Basic Attributes

Molecular Weight：

455.58982

Exact Mass：

455.17600

EC Number：

200-659-6

UNII：

SJT761GEGS

DEA Code Number：

1205

DSSTox ID：

DTXSID60209653

NCI Thesaurus Code：

C76628

Characteristics

PSA：

207

XLogP3：

4.15120

Boiling Point：

488ºC at 760 mmHg

Flash Point：

9℃

Storage Conditions：

-20°C

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

11-23/24/25-39/23/24/25

safety instructions：

7-16-36/37-45

Marks：

F,T

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

Drug Information

MeSH：

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)|Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake. (See all compounds classified as Dopamine Uptake Inhibitors.)

MeSH Entry Terms：

Dimesylate, Lis-dexamfetamine

DEA Controlled Substances：

Lisdexamfetamine|Vyvanse|1205|Schedule II - Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|No

Lisdexamfetamine dimesylate Use and Manufacturing

Uses

Treatment of atten tion deficit hyperactivity disorder (ADHD).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:455.6
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:455.17599275
Monoisotopic Mass:455.17599275
Topological Polar Surface Area:207
Heavy Atom Count:29
Complexity:344
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Guangzhou Yaoguang Technology Co., Ltd. Contact Supplier

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608137-33-3

CAS No.: 608137-33-3

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Guide of Lisdexamfetamine dimesylate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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