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Home > Encyclopedia > N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine

N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine

N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine structure

N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine 

structure
  • CAS No:

    57292-44-1

  • Formula:

    C14H18ClNO4

  • Chemical Name:

    N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine

  • Synonyms:

    D-Phenylalanine,4-chloro-N-[(1,1-dimethylethoxy)carbonyl]-;4-Chloro-N-[(1,1-dimethylethoxy)carbonyl]-D-phenylalanine;BOC-4-chloro-D-phenylalanine;N-(tert-Butoxycarbonyl)-4-chloro-D-phenylalanine;N-tert-Butoxycarbonyl-p-chloro-D-phenylalanine;N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine;(R)-2-[(tert-Butoxycarbonyl)amino]-3-(4-chlorophenyl)propionic acid;(R)-2-tert-Butoxycarbonylamino-3-(4-chlorophenyl)propionic acid;(2R)-2-(tert-Butoxycarbonylamino)-3-(4-chlorophenyl)propanoic acid;(R)-2-((tert-Butoxycarbonyl)amino)-3-(4-chlorophenyl)propanoic acid

  • Categories:

    Pharmaceutical Intermediates  >  Antineoplastics

Description

white powder

N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine Basic Attributes

299.75

299.75

611-492-7

2924299090

Characteristics

75.6

2.4

White Powder

1.2±0.1 g/cm3

~110 °C

452.5°C at 760 mmHg

227.5±27.3 °C

1.539

Store at RT.

-24 º (c=1,EtOH)

Safety Information

IRRITANT

NONH for all modes of transport

3

24/25

Xi

N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine Use and Manufacturing

Methods of Manufacturing

The D-4-chlorophenylalanine crude product (22.0 mg, 0.110 mmol) was dissolved in water (2 mL) and acetone (1.0 mL). To the solution, a solution of (Boc)D-4- chlorophenylalanine crude product (22.0 mg, 0.110 mmol) was dissolved in water (2 mL) and acetone (1.0 mL), (Boc) 2General procedure: L-Phenylalanine (1.0 g, 6.05 mmol) and sodium carbonate (0.71 g, 6.70 mmol) in water (10 mL) was reacted with a solution of 2 (1.89 g, 6.36 mmol) in acetone (10 mL). The reaction mixture was stirred at room temperature till the reaction completes, as monitored by TLC. The resulting solution was concentrated, to the residue was added water (10 mL) and ethyl acetate (10 mL), pH adjusted to 6.0 with 10percent KHSO

Uses

N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine, is one of the phenylalanine derivatives, that can be used for the synthesis of THIQ (C380165), which is a selective melanocortin 4 receptor.

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