Sodium iodide

149.89400

149.89400

231-679-3

F5WR8N145C

1009

77388

DTXSID2041125

COLORLESS, CUBIC CRYSTALS|WHITE CRYSTALS OR GRANULES|WHITE POWDER

2827600000

0

-2.99600

DryPowder; Liquid; PelletsLargeCrystals

3.67 g/cm³

651 °C

1304 °C

1300-1304ºC

1.7745

H2O: 184 g/100 mL (25 ºC)

Store at RT.

1 hPa (767 °C)

>1 (vs air)

MLD i.v. in rats: 1.3 g/kg, Loeser, Konwiser, J. Lab. Clin. Med. 15, 35 (1929)

ODORLESS

SALINE, SOMEWHAT BITTER TASTE

8-9.5

AT ROOM TEMP CRYSTALLIZES FROM WATER WITH 2H2O IN FORM OF COLORLESS, PRISMATIC CRYSTALS|RAPIDLY ATTACKED BY BROMINE TRIFLUORIDE

UN 3077 9 / PGIII

1

R36/38

S26

WB6475000

Xi

Separated from strong oxidants and food and feedstuffs. Dry. Well closed.

hygroscopic

P273-P305 + P351 + P338

H315-H319-H400

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H315 (49.68%): Causes skin irritation [Warning Skin corrosion/irritation]|P260, P261, P264, P270, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P314, P321, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 506 companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

In case of fire in the surroundings, use appropriate extinguishing media.

PERCHLORIC ACID IGNITES IN CONTACT WITH SODIUM IODIDE.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers.

Separated from strong oxidants and food and feedstuffs. Dry. Well closed.

A harmful concentration of airborne particles can be reached quickly , especially if powdered.

The substance is irritating to the eyes, skin and respiratory tract.

Ingestion may cause effects on the thyroid. May cause systemic sensitization.

PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF (PREGNANT) WOMEN!

Use ventilation (not if powder), local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection if powder.

Acute oral LD50 is 4340 mg/kg in rat and 1000 mg/kg in mouse [MSDS]. Chronic iodide overdoses may result in iodism, which is commonly characterized by salivation, coryza, sneezing, conjunctivitis, headache, fever, laryngitis, bronchitis, stomatitis, parotitis and oedema of the glottis. Up to 10g of sodium iodide has been administered intravenously without any signs of toxicity.

...LITHIUM CARBONATE THEORETICALLY COULD INTERACT WITH...SODIUM IODIDE.

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

...CAN BE USED INTERCHANGEABLY WITH POTASSIUM IODIDE, AS A THERAPEUTIC AGENT, EXCEPT WHERE SODIUM ION IS CONTRAINDICATED.|VET: HAS BEEN USED FOR RINGWORM, HYPERPLASTIC FIBROUS LESIONS, PARAPLEGIA FROM PACHYMENINGITIS OF DOGS.|VET: ...IT MAY BE USEFUL IV FOR OTHER MYCOSES, CHRONIC JOINT SWELLINGS, LARYNGITIS, BRONCHITIS, & PLEURITIS IN MANY SPECIES; LUNGWORM INFECTIONS IN CATS; TO IMMOBILIZE THALLIUM IN THE BODY; BY CATHETER INTO THE BLADDER AS AN X-RAY CONTRAST MEDIA...|DOSE--ORAL, 300 MG TO 2 G DAILY; USUAL, 300 MG 2-4 TIMES A DAY; IV INFUSION, 1-3 G DAILY; USUAL, 1 G.|For more Therapeutic Uses (Complete) data for SODIUM IODIDE (15 total), please visit the HSDB record page.

VET: ...MONITOR IODISM. AVOID UNNECESSARY USE IN ADVANCED PREGNANCY...IT MAY PRODUCE GOITER IN NEWBORN. .../AVOID/ USE OF MILK FROM TREATED ANIMALS FOR AT LEAST 72 HR & 6 MILKINGS AFTER SUCH TREATMENT. MAY POTENTIATE BARBITURATE ANESTHESIA IN RATS.|IODIDES MAY PPT THYROTOXICOSIS WHEN GIVEN TO PT WITH NODULAR GOITERS, OR IN EUTHYROID PT WITH AUTONOMOUS THYROID FUNCTION...DURING REMISSION OF HYPERTHYROIDISM FOLLOWING A COURSE OF THIONAMIDES... IN PT WITH CHRONIC THYROIDITIS, PREVIOUS RADIOIODINE THERAPY OR THYROIDECTOMY, IODIDES MAY INDUCE HYPOTHYROIDISM. /IODIDES/|CONTRAINDICATIONS (VET): HYPERTHYROIDISM & PREGNANCY. WARNING: ANIMALS VARY IN SUSCEPTIBILITY TO IODIDES. ADMIN WITH CAUTION UNTIL TOLERANCE IS DETERMINED. DISCONTINUE TREATMENT IMMEDIATELY IF SYMPTOMS OF IODISM APPEAR... /SODIUM IODIDE 20%/|POTENTIAL ADVERSE EFFECTS ON FETUS: Goiters, fetal encephalopathy. POTENTIAL SIDE EFFECTS ON BREAST-FED INFANT: May cause skin rash and thyroid suppression in infant. FDA Category:D (D = There is no evidence of human fetal risk but the potential benefits from use in pregnant women may be acceptable despite the potential risks (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective.) /Iodides/ /from table II/

3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OUNCE & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). /IODIDE SALTS/

When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms.

Iodide salts are readily absorbed in the gastrointestinal tract.|Iodides are expected to be renal excreted.|Iodides are distributed widely throughout extracellular fluid of thyroid gland.

RESPONSE TO IODIDE IN HYPERTHYROIDISM: /IN THYROID GLAND/...VASCULARITY IS REDUCED, GLAND BECOMES MUCH FIRMER & EVEN HARD TO THE TOUCH, CELLS BECOME SMALLER, COLLOID REACCUMULATES IN FOLLICLES, & QUANTITY OF BOUND IODINE INCREASES. /IODIDES/|HIGH CONCN OF IODIDE APPEAR TO INFLUENCE ALL IMPORTANT ASPECTS OF IODINE METABOLISM BY THE THYROID GLAND. CAPACITY OF IODIDE TO LIMIT ITS OWN TRANSPORT... ACUTE INHIBITION OF SYNTHESIS OF IODOTYROSINE & IODOTHYRONINE BY IODIDE IS ALSO WELL KNOWN (THE WOLFF-CHAIKOFF EFFECT)... /IODIDES/|THIS INHIBITION /WOLFF-CHAIKOFF EFFECT/ IS OBSERVED ONLY ABOVE CRITICAL CONCN OF IODIDE, & THE INTRACELLULAR...CONCN OF ANION APPEARS TO BE MAJOR DETERMINANT. WITH TIME THERE IS "ESCAPE" FOR THIS INHIBITION...ASSOCIATED WITH AN ADAPTIVE DECR IN IODIDE TRANSPORT & LOWERED INTRACELLULAR IODIDE CONCN. /IODIDES/|THE MOST IMPORTANT CLINICAL EFFECT OF HIGH IODIDE CONCN IS AN INHIBITION OF THE RELEASE OF THYROID HORMONE. THIS ACTION IS RAPID & EFFICACIOUS IN SEVERE THYROTOXICOSIS. THE EFFECT IS EXERTED DIRECTLY ON THE THYROID GLAND, & IT CAN BE DEMONSTRATED IN EUTHYROID SUBJECT & EXPTL ANIMALS AS WELL AS IN HYPERTHYROID PT. /IODIDES/|IODIDE ANTAGONIZES THE ABILITY OF BOTH THYROTROPIN & CYCLIC AMP TO STIMULATE ENDOCYTOSIS OF COLLOID, PROTEOLYSIS, & HORMONE SECRETION. /REPORTEDLY/... IODIDE ATTENUATES THE EFFECT OF TSH ON CYCLIC AMP IN VIVO & IN ISOLATED TISSUES. /IODIDES/

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

THE OCCASIONAL USE OF IODIDES FOR ASTHMA IN PREGNANCY HAS RESULTED IN FETAL DEATH, SEVERE GOITER & CRETINOID APPEARANCE OF THE NEWBORN. /IODIDE SALTS/|..."IODISM" RESULTS FROM CHRONIC IODIDE OVERDOSES... IODISM IS CHARACTERIZED BY SALIVATION, CORYZA, SNEEZING, CONJUNCTIVITIS, HEADACHE, FEVER, LARYNGITIS, BRONCHITIS, STOMATITIS, PAROTITIS...&...EDEMA OF GLOTTIS...HAS OCCURRED. /IODIDE SALTS/|TEN GRAMS OF SODIUM IODIDE HAVE BEEN GIVEN SLOWLY BY IV ROUTE WITHOUT ILL EFFECTS.|OCCASIONAL INDIVIDUALS SHOW...SENSITIVITY TO IODIDE OR TO ORG PREPN THAT CONTAIN IODINE WHEN...ADMIN IV. ONSET OF AN ACUTE REACTION MAY OCCUR IMMEDIATELY OR SEVERAL HR AFTER ADMIN. ANGIOEDEMA IS OUTSTANDING SYMPTOM, & SWELLING OF LARYNX MAY LEAD TO SUFFOCATION. MULTIPLE CUTANEOUS HEMORRHAGES MAY BE PRESENT. /IODIDE PREPN/|For more Human Toxicity Excerpts (Complete) data for SODIUM IODIDE (10 total), please visit the HSDB record page.

Sodium Iodide

The substance can be absorbed into the body by ingestion.

Cough. Sore throat. Headache.

Redness.

Redness.

USP SODIUM IODIDE IS AT LEAST 99% PURE.|GRADES: TECHNICAL; CP; USP; SINGLE CRYSTALS.|FORMULATIONS (VET): EACH 100 ML CONTAINS SODIUM IODIDE USP 20 G; INERT INGREDIENTS, FORMALDEHYDE (AS PRESERVATIVE) 0.2% WEIGHT/VOLUME, DISTILLED WATER 82.4% WEIGHT/WEIGHT. /SODIUM IODIDE 20%/|/Available in/ high purity, ultra-dry grades & 57% solution grades|NaI-USP XX contains 99-101.5% NaI calc on the anhydrous basis

All other basic inorganic chemical manufacturing|Sodium iodide (NaI): ACTIVE|INCOMPATIBILITIES: SEE POTASSIUM IODIDE. ALKALOIDAL SALTS, CHLORAL HYDRATE, TARTARIC & OTHER ACIDS, CALOMEL, POTASSIUM CHLORATE, METALLIC SALTS. /POTASSIUM IODIDE/

Cosmetics -> Antimicrobial