FMOC-D-Valine
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FMOC-D-Valine
structure -
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CAS No:
84624-17-9
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Formula:
C20H21NO4
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Chemical Name:
FMOC-D-Valine
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Synonyms:
(R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid;Fmoc-D-Val-OH >=98.0% (HPLC);Fmoc-D-valine≥ 99% (HPLC);N-FMOC-D-VALINE;N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-VALINE;N-9-FLUORENYLMETHYLOXYCARBONYL-D-VALINE;N-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE
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CAS No:
Characteristics
75.6
4
White to off-white crystalline powder
1.2±0.1 g/cm3
143-144 °C(lit.)
287.5±25.4 °C
1.590
Solubility in methanol (almost transparency). Slightly soluble in water.
2-8°C
17 º (c=1, DMF)
Safety Information
NONH for all modes of transport
3
22-24/25
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
FMOC-D-Valine Use and Manufacturing
Take 500mL of the reaction bottle, Chiral amino acids R-3a (4.5 g, 38.9 mmol) were added to the reaction flask, respectively, Dioxane (40 mL) and10percent sodium carbonate (100 mL), The reaction flask was placed in an ice bath, Mechanical agitation, To the dropping funnel was added chloroform-9-fluorenylmethyl ester (10.0 g, 38.8 mmol)And dioxane (100 mL), Slowly drop into the reaction flask and gradually return to room temperature and stir overnight.After completion of the reaction, add water 100mL, extracted with 50mL ether three times, take the water phase into the ice bath to cool, add 1M dilute HCl to PH 1.The aqueous solution was extracted three times with 50 mL of ethyl acetate.The oil phase was combined and dried over magnesium sulfate, Filtration followed by drying to give intermediate R-4a (12.6 g, 96percent).
Computed Properties
Molecular Weight:339.4
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:339.14705815
Monoisotopic Mass:339.14705815
Topological Polar Surface Area:75.6
Heavy Atom Count:25
Complexity:470
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryUnit Price: $1 /KG FOBCAS No.: 84624-17-9Grade: Pharmaceutical GradeContent: 99%
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