8-CHLOROADENOSINE
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8-CHLOROADENOSINE
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CAS No:
34408-14-5
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Formula:
C10H12ClN5O4
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Chemical Name:
8-CHLOROADENOSINE
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Synonyms:
8-CL-ADO;8-CHLOROADENOSINE;ADENOSINE, 8-CHLORO;8-Chloro-D-adenosine;8-Cl-rA
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CAS No:
Description
8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia).|8-Chloroadenosine is an antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis.
Computed Properties
Molecular Weight:301.69
XLogP3:-0.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:301.0577816
Monoisotopic Mass:301.0577816
Topological Polar Surface Area:140
Heavy Atom Count:20
Complexity:367
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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