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JAK3 Inhibitor I

JAK3 Inhibitor I structure

CAS No:
211555-05-4
Formula:
C16H13Br2N3O3
Chemical Name:
JAK3 Inhibitor I
Synonyms:
WHI-P 974-(3',5'-DibroMo-4-hydroxyphenyl)aMino-6,7-diMethoxyquinazoline;2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
Categories:
Biochemical Engineering > Inhibitors

Description

WHI-P97 is a rationally designed potent inhibitor of JAK-3.IC50 value:Target: JAK3Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without a

2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol is a member of quinazolines.

JAK3 Inhibitor I Basic Attributes

Molecular Weight：

455.10072

Exact Mass：

452.93200

EC Number：

-0

DSSTox ID：

DTXSID20274408

Characteristics

PSA：

76.50000

XLogP3：

4.69420

Density：

1.785

Drug Information

MeSH Entry Terms：

4-(3',5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline

Computed Properties

Molecular Weight:455.10
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:454.93032
Monoisotopic Mass:452.93237
Topological Polar Surface Area:76.5
Heavy Atom Count:24
Complexity:408
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes