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GSK-3BETA INHIBITOR XII

GSK-3BETA INHIBITOR XII structure

CAS No:
601514-19-6
Formula:
C18H14N4O2
Chemical Name:
GSK-3BETA INHIBITOR XII
Synonyms:
TWS119;GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119;TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol;GSK-3β Inhibitor, TWS119
Categories:
Biochemical Engineering > Inhibitors

Description

TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

Molecular Weight：

318.335

Exact Mass：

318.111664

PSA：

XLogP3：

3.2

Density：

1.4±0.1 g/cm3

Boiling Point：

646.0±55.0°C at 760 mmHg

Flash Point：

344.5±31.5 °C

Refractive Index：

1.753

Storage Conditions：

Desiccate at +4°C

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313

Hazard Statements：

H302-H319

Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.

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