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SR 1078

SR 1078 structure

CAS No:
1246525-60-9
Formula:
C17H10F9NO2
Chemical Name:
SR 1078
Synonyms:
SR 1078;SR1078,N-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-4-trifluoroMethyl-benzaMide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamideSR1078;N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-4-(trifluoromethyl)benzamide
Categories:
Biochemical Engineering > Inhibitors

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SR 1078 Basic Attributes

Molecular Weight：

431.2524288

Exact Mass：

431.057

Characteristics

PSA：

49.3

XLogP3：

4.8

Density：

1.527±0.06 g/cm3(Predicted)

Melting Point：

169℃

Boiling Point：

362.9±42.0 °C(Predicted)

SR 1078 Use and Manufacturing

Under argon, to a solution of 4-(l -Hydroxy- l-trifluoromethyl-2, 2, 2- trifluoroethyl)aniline (1.5M in THF, 128 μ, , 0.193 mmol) in CH2C12 (275 μ.) were successively added at room temperature N, N-Diisopropylethylamine (37 uL, 0.212 mmol) and 4-(Trifluoromethyl)benzoyl chloride (30 μ, 0.193 mmol). The mixture was stirred for 8 hours and concentrated under reduce pressure. The crude residue was directly purified by column chromatography on silica gel without any work-up by Hexane/AcOEt (8/2) to obtain 59 mg (71percent) of SR1078 as a white powder.FTIR: 3404, 3214, 1671, 1602, 1529, 1417, 1322, 1272, 1206, 1190, 1176, 1138, 1117, 1065, 1016, 973, 964, 948, 902, 857, 830, 765, 752, 737, 704, 692 cm