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Motesanib diphosphate

Motesanib diphosphate structure

CAS No:
857876-30-3
Formula:
C22H23N5O.2H3O4P
Chemical Name:
Motesanib diphosphate
Synonyms:
3-Pyridinecarboxamide,N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-,phosphate (1:2);Motesanib diphosphate;AMG 706
Categories:
Biochemical Engineering > Inhibitors

Description

Motesanib Diphosphate is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.

Motesanib Diphosphate is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

Motesanib diphosphate Basic Attributes

Molecular Weight：

569.448

Exact Mass：

569.144043

UNII：

T6Q3060U91

DSSTox ID：

DTXSID30235080

NCI Thesaurus Code：

C48374

Characteristics

PSA：

235

XLogP3：

2.78190

Boiling Point：

858.7°C at 760 mmHg

Flash Point：

473.1ºC

Drug Information

MeSH：

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

MeSH Entry Terms：

AMG 706

Motesanib diphosphate Use and Manufacturing

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

Computed Properties

Molecular Weight:569.4
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:5
Exact Mass:569.14405151
Monoisotopic Mass:569.14405151
Topological Polar Surface Area:235
Heavy Atom Count:38
Complexity:583
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Motesanib Diphosphate(AMG-706)

CAS No.: 857876-30-3

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