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SU 11274

SU 11274 structure

CAS No:
658084-23-2
Formula:
C28Cl1H30N5O4S1
Chemical Name:
SU 11274
Synonyms:
PKI-SU11274;N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide;SU11274(PKI-SU11274);Sul1274;SU 11274，SU 11274;(Z)-N-(3-chlorophenyl)-3-((3,5-diMethyl-4-(4-Methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)Methylene)-N-Methyl-2-oxoindoline-5-sulfonaMide;(Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(1-methylpiperazine-4-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide;N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamideSU11274
Categories:
Biochemical Engineering > Inhibitors

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Description

SU11274 is a selective Met inhibitor with IC50 of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2.

SU 11274 Basic Attributes

Molecular Weight：

568.09

Exact Mass：

567.170715

NSC Number：

747693

DSSTox ID：

DTXSID20429552

Characteristics

PSA：

114

XLogP3：

2.15

Appearance：

orange powder

Density：

1.4±0.1 g/cm3

Refractive Index：

1.664

Water Solubility：

DMSO: 10 mg/mL at 60 °C

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)

Computed Properties

Molecular Weight:568.1
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:567.1707033
Monoisotopic Mass:567.1707033
Topological Polar Surface Area:114
Heavy Atom Count:39
Complexity:1070
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes