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GSK J4 HCl

GSK J4 HCl structure

CAS No:
1373423-53-0
Formula:
C24H27N5O2
Chemical Name:
GSK J4 HCl
Synonyms:
GSK J4 HCl;GSK J4;GSK-J4;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1);Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate;Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)prop
Categories:
Biochemical Engineering > Inhibitors

Description

GSK-J4 is a potent H3K27me3 histone lysine demethylase (KDM) inhibitor, with IC50s of 8.6 μM and 6.6 μM against KDM6B and KDM6A, respectively.

Molecular Weight：

417.50348

Exact Mass：

417.216461

PSA：

80.24000

XLogP3：

3.75

Appearance：

white to beige

Density：

1.216±0.06 g/cm3(Predicted)

Boiling Point：

581.2±50.0 °C(Predicted)

Flash Point：

305.3±30.1 °C

Refractive Index：

1.615

Water Solubility：

DMSO: soluble20mg/mL, clear

Storage Conditions：

2-8°C

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315